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- W4248442521 abstract "Fmoc amino acid fluorides were found to be exceptionally well suited for the coupling of extremely hindered amino acids using a new strategy involving treatment with bis(trimethylsilyl)acetamide prior to the acylation step. Addition of bis(trimethylsilyl)acetamide (BSA) accelerates peptide bond formation of extremely hindered amino acids. Fmoc-NMeAib-F + Aib-OMe + BSA → Fmoc-NMeAib-Aib-OMe Yield: 34%, 2h (without BSA: 8%)" @default.
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- W4248442521 date "1996-07-01" @default.
- W4248442521 modified "2023-10-17" @default.
- W4248442521 title "Fmoc amino acid fluorides in peptide synthesis — Extension of the method to extremely hindered amino acids" @default.
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- W4248442521 doi "https://doi.org/10.1016/0040-4039(96)01160-4" @default.
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