Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248455345> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W4248455345 endingPage "809" @default.
- W4248455345 startingPage "803" @default.
- W4248455345 abstract "This study was designed to determine the extent by which mild or moderate hypothermia attenuates the triggering of malignant hyperthermia (MH) induced by the combined administration of halothane and succinylcholine.Sixteen susceptible swine were initially anesthetized with nontriggering drugs and then either kept normothermic (approximate equals 38 degrees C, n = 6) or cooled to induce mild (approximate equals 35 degrees C, n = 6), or moderate (approximate equals 33 degrees C, n = 4) hypothermia. Next, after a 30-min control period, the normothermic and mildly hypothermic animals were administered 1 minimum alveolar anesthetic concentration (MAC) halothane followed by a bolus dose of succinylcholine (2 mg/kg). Within 10 min all normothermic animals developed fulminant MH, whereas the onset of MH was slowed or was absent in the mildly hypothermic group. To test whether moderate hypothermia could more effectively minimize the signs of a MH episode, this group of animals was exposed to 1.5 MAC halothane followed 10 min later by a 3-mg/kg bolus of succinylcholine. MH was not induced and anesthesia was then changed to nontriggering drugs (ketamine and pancuronium). The animals were then aggressively rewarmed to 38 degrees C: a slight increase in the ETCO2 was detected, but MH episodes did not spontaneously occur. Subsequently, the readministration of halothane and succinylcholine rapidly provoked fulminant MH. We concluded that the induction of mild hypothermia impairs triggering and reduces the progression of MH induced by the combined administration of halothane and succinylcholine, whereas moderate hypothermia was completely protective and thus could be considered for prophylaxis. (Anesth Analg 1996;82:803-9)" @default.
- W4248455345 created "2022-05-12" @default.
- W4248455345 creator A5001633403 @default.
- W4248455345 creator A5024721965 @default.
- W4248455345 creator A5029343967 @default.
- W4248455345 creator A5038966090 @default.
- W4248455345 creator A5042996287 @default.
- W4248455345 date "1996-04-01" @default.
- W4248455345 modified "2023-09-25" @default.
- W4248455345 title "Prior Hypothermia Attenuates Malignant Hyperthermia in Susceptible Swine" @default.
- W4248455345 doi "https://doi.org/10.1213/00000539-199604000-00022" @default.
- W4248455345 hasPublicationYear "1996" @default.
- W4248455345 type Work @default.
- W4248455345 citedByCount "2" @default.
- W4248455345 crossrefType "journal-article" @default.
- W4248455345 hasAuthorship W4248455345A5001633403 @default.
- W4248455345 hasAuthorship W4248455345A5024721965 @default.
- W4248455345 hasAuthorship W4248455345A5029343967 @default.
- W4248455345 hasAuthorship W4248455345A5038966090 @default.
- W4248455345 hasAuthorship W4248455345A5042996287 @default.
- W4248455345 hasConcept C126322002 @default.
- W4248455345 hasConcept C141071460 @default.
- W4248455345 hasConcept C2776932660 @default.
- W4248455345 hasConcept C2777390192 @default.
- W4248455345 hasConcept C2778162923 @default.
- W4248455345 hasConcept C2778575482 @default.
- W4248455345 hasConcept C2779949491 @default.
- W4248455345 hasConcept C2780795376 @default.
- W4248455345 hasConcept C2781107259 @default.
- W4248455345 hasConcept C3020190219 @default.
- W4248455345 hasConcept C42219234 @default.
- W4248455345 hasConcept C43376680 @default.
- W4248455345 hasConcept C71924100 @default.
- W4248455345 hasConceptScore W4248455345C126322002 @default.
- W4248455345 hasConceptScore W4248455345C141071460 @default.
- W4248455345 hasConceptScore W4248455345C2776932660 @default.
- W4248455345 hasConceptScore W4248455345C2777390192 @default.
- W4248455345 hasConceptScore W4248455345C2778162923 @default.
- W4248455345 hasConceptScore W4248455345C2778575482 @default.
- W4248455345 hasConceptScore W4248455345C2779949491 @default.
- W4248455345 hasConceptScore W4248455345C2780795376 @default.
- W4248455345 hasConceptScore W4248455345C2781107259 @default.
- W4248455345 hasConceptScore W4248455345C3020190219 @default.
- W4248455345 hasConceptScore W4248455345C42219234 @default.
- W4248455345 hasConceptScore W4248455345C43376680 @default.
- W4248455345 hasConceptScore W4248455345C71924100 @default.
- W4248455345 hasIssue "4" @default.
- W4248455345 hasLocation W42484553451 @default.
- W4248455345 hasOpenAccess W4248455345 @default.
- W4248455345 hasPrimaryLocation W42484553451 @default.
- W4248455345 hasRelatedWork W1571555654 @default.
- W4248455345 hasRelatedWork W2002560062 @default.
- W4248455345 hasRelatedWork W2019828029 @default.
- W4248455345 hasRelatedWork W2030447016 @default.
- W4248455345 hasRelatedWork W2049847358 @default.
- W4248455345 hasRelatedWork W2134270269 @default.
- W4248455345 hasRelatedWork W2369114751 @default.
- W4248455345 hasRelatedWork W2411935166 @default.
- W4248455345 hasRelatedWork W2412958953 @default.
- W4248455345 hasRelatedWork W4254856975 @default.
- W4248455345 hasVolume "82" @default.
- W4248455345 isParatext "false" @default.
- W4248455345 isRetracted "false" @default.
- W4248455345 workType "article" @default.