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• W4248514523 abstract "INTRODUCTION: Knowledge of gender differences is important in optimization of individual outcomes. Female sex, however, has been unclear in its association with prognostic indicators, disease severity, and mortality in alcoholic liver cirrhosis (ALC). We assessed several widely-used laboratory values and comorbid conditions for female patients with ALC after initial hospitalization at Carilion Clinic in southwest Virginia. Individual risk factors were then assessed for its relationship with mortality. METHODS: Carilion Clinic’s electronic medical record (EPIC) was studied to identify all alcoholic patients hospitalized for the first time with either a new or prior diagnosis of alcoholic cirrhosis from 2008 to 2016 with follow-up through June 2018. Information on demographics, comorbidities, lab values, and mortality were extracted. The cumulative risks of mortality after the first hospitalization were estimated using Kaplan-Meier curves and compared among the female population. Demographic data, lab values, and comorbidities associated with cirrhosis were assessed using multivariate Cox proportional hazard analysis to determine risk factors associated with mortality. RESULTS: We identified 78 female patients (mean 51.10 ± 11.60 years) hospitalized at Carilion Clinic with diagnosis of ALC. About 46% endorsed alcohol use at the time of admission, 13% endorsed illicit drug use, and 56% endorsed tobacco use. The 1, 3- and 5- year cumulative mortality after the first hospitalization was 24.1%, 59.0% and 67.2%, respectively. On multivariate Cox proportional hazard analysis, presence of hepatic encephalopathy on admission and BUN levels at time of discharge were both associated with increased risk of mortality (Table 1). The median survival for younger female patients with ALC (age < 40 years old) after first hospitalization, however, was not statistically significant compared to the older female patients (age > 40 years) (4.24 yrs vs. 0.72 yrs, respectively; P = 0.133) (Figure 1). CONCLUSION: For female patients with newly diagnosed alcoholic cirrhosis, various risk factors are associated with undesirable outcomes. Female patients, especially presenting with hepatic encephalopathy, should be monitored closely and considered for referral for liver transplant evaluation if they do not respond to standard of care management.Table 1.: Risk Factors of Female Patients associated with Mortality in Alcoholic Liver CirrhosisFigure 1.: Mortality of Young vs. Old Female Patients with ALC after First Hospitalization." @default.
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• W4248514523 date "2020-10-01" @default.
• W4248514523 modified "2023-09-26" @default.
• W4248514523 title "S3269 Survival and Risk Factors Contributing to Mortality in Female Patients Hospitalized With Alcoholic Liver Cirrhosis" @default.
• W4248514523 doi "https://doi.org/10.14309/01.ajg.0000715124.97327.62" @default.
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