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- W4248520384 abstract "<h3>To the Editor.</h3> —Concern about recent studies linking vasectomy and prostate cancer has been tempered by the absence of any clear biologic rationale for the association. In dismissing as unlikely a role for hormonal mechanisms, Giovannucci et al<sup>1</sup>have overlooked evidence that may be linked to prostate cancer by disrupting gametogenesis and increasing gonadotropins. This mechanism is similar to that proposed for ovarian cancer,<sup>2</sup>which may share other epidemiologic features with prostate cancer. Experimental studies show that ligation of the vas causes Sertoli cell damage and Leydig cell hypertrophy. Seventy years ago, Steinach<sup>3</sup>recognized this effect in men and proposed vasoligation to rejuvenate aging men after observing that it produced a cycle of growth... of the male generative gland by causing the expansion of the interstitial tissue at the expense of the generative tissue. Sertoli cell damage may decrease inhibins with a consequent increase in follicle-stimulating hormone." @default.
- W4248520384 created "2022-05-12" @default.
- W4248520384 date "1993-08-11" @default.
- W4248520384 modified "2023-09-27" @default.
- W4248520384 doi "https://doi.org/10.1001/jama.270.6.707" @default.
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