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- W4248527076 abstract "Hydrogen–tritium exchange (HX) techniques allow the accurate measurement of numbers and rates of exchanging hydrogens of macromolecules. The earlier techniques have experienced continued refinement to allow more reliable HX measurement with smaller quantities of material and at earlier exchange times. Exchangeable H sites are first labeled with tritium (T) during a pre-equilibration exchange-in period in the presence of added THO. The involvement of exchangeable H in stable macromolecular structure greatly slows their exchange rate. Thus, the number of abnormally slowed H provides a measure of quantity of structure. Then exchange-out of bound T is initiated by separating T-labeled macromolecule from free THO using a Sephadex column. Manipulations allow the measurement of T remaining bound to the macromolecule as exchange-out time proceeds. In an analysis of HX data to convert measured counts of bound T to the computed number of unexchanged H, it is necessary to know the count level of T in the equilibration mix." @default.
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- W4248527076 date "1972-01-01" @default.
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- W4248527076 title "[19] Hydrogen-tritium exchange" @default.
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- W4248527076 doi "https://doi.org/10.1016/s0076-6879(72)26021-9" @default.
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