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- W4248582145 abstract "Abstract Background : Perivascular fluid flow, of cerebrospinal or interstitial fluid in spaces surrounding brain blood vessels, is recognized as a key component underlying brain transport and clearance. An important open question is how and to what extent differences in vessel type or geometry affect perivascular fluid flow and transport. Methods : Using computational modelling in both idealized and image-based geometries, we study and compare fluid flow and solute transport in pial (surface) periarterial and perivenous spaces. Results : Our findings demonstrate that differences in geometry between arterial and venous pial perivascular spaces (PVSs) lead to higher net CSF flow, more rapid tracer transport and earlier arrival times of injected tracers in periarterial spaces compared to perivenous spaces. Conclusions : These findings can explain the experimentally observed rapid appearance of tracers around arteries, and the delayed appearance around veins without the need of a circulation through the parenchyma, but rather by direct transport along the PVSs." @default.
- W4248582145 created "2022-05-12" @default.
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- W4248582145 date "2021-03-29" @default.
- W4248582145 modified "2023-09-27" @default.
- W4248582145 title "Brain solute transport is more rapid in periarterial than perivenous spaces" @default.
- W4248582145 doi "https://doi.org/10.21203/rs.3.rs-361955/v1" @default.
- W4248582145 hasPublicationYear "2021" @default.
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