Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248622847> ?p ?o ?g. }
- W4248622847 endingPage "130" @default.
- W4248622847 startingPage "123" @default.
- W4248622847 abstract "Abstract Context—Although genome-wide imbalances have been characterized in conventional adenoid cystic carcinoma, other than p53 mutational status, the molecular profile of adenoid cystic carcinoma with high-grade transformation has not been explored. Objective—To evaluate progressive genetic alterations in adenoid cystic carcinoma with high-grade transformation using array comparative genomic hybridization. Design—Five adenoid cystic carcinomas with high-grade transformation (4 primary tumors and 1 paired metastasis) were selected and characterized at the DNA level by array comparative genomic hybridization on formalin-fixed paraffin-embedded tissue. Select alterations were validated by fluorescence in situ hybridization. Results—Chromosomal gains were mostly confined to the areas of high-grade transformation while losses were seen only in the conventional areas. Chromosomal regions with significant gains included 8q24, 17q11.2-q12, 17q23, and 15q11-13. Regions that showed the significant losses included 9q34, 4p16, 1p36.1, and 11q22. Fluorescence in situ hybridization analysis demonstrated increases in C-MYC (8q24.12-q24.13) and a low level increases in ERBB2 (formerly HER2/neu) (17q11.2-q12) in cases showing gains by array comparative genomic hybridization in these regions. However, no tumor showed HER2/neu immunopositivity. Conclusions—High-grade transformation in adenoid cystic carcinoma is a complex process that is reflected by several chromosomal alterations. Our findings implicate C-MYC amplification in this progression, although the role of HER2/neu is still unclear. Other candidate oncogenes, particularly on chromosome 17q23, warrant investigation in this rare tumor." @default.
- W4248622847 created "2022-05-12" @default.
- W4248622847 creator A5024067229 @default.
- W4248622847 creator A5029367587 @default.
- W4248622847 creator A5030798278 @default.
- W4248622847 creator A5056955251 @default.
- W4248622847 date "2011-01-01" @default.
- W4248622847 modified "2023-10-03" @default.
- W4248622847 title "Progressive Genetic Alterations of Adenoid Cystic Carcinoma With High-Grade Transformation" @default.
- W4248622847 cites W1501188525 @default.
- W4248622847 cites W1971041688 @default.
- W4248622847 cites W1984668522 @default.
- W4248622847 cites W1987763776 @default.
- W4248622847 cites W1987824119 @default.
- W4248622847 cites W1987837110 @default.
- W4248622847 cites W1990902084 @default.
- W4248622847 cites W1999959255 @default.
- W4248622847 cites W2002956646 @default.
- W4248622847 cites W2004969024 @default.
- W4248622847 cites W2009047889 @default.
- W4248622847 cites W2009625056 @default.
- W4248622847 cites W2010139701 @default.
- W4248622847 cites W2010335867 @default.
- W4248622847 cites W2017785964 @default.
- W4248622847 cites W2019488285 @default.
- W4248622847 cites W2021982612 @default.
- W4248622847 cites W2028544651 @default.
- W4248622847 cites W2028590172 @default.
- W4248622847 cites W2029256673 @default.
- W4248622847 cites W2049332511 @default.
- W4248622847 cites W2053640834 @default.
- W4248622847 cites W2056826996 @default.
- W4248622847 cites W2062447494 @default.
- W4248622847 cites W2063882982 @default.
- W4248622847 cites W2068087217 @default.
- W4248622847 cites W2068347820 @default.
- W4248622847 cites W2069633722 @default.
- W4248622847 cites W2071964689 @default.
- W4248622847 cites W2072946290 @default.
- W4248622847 cites W2079837887 @default.
- W4248622847 cites W2082668371 @default.
- W4248622847 cites W2085043050 @default.
- W4248622847 cites W2088308108 @default.
- W4248622847 cites W2088325873 @default.
- W4248622847 cites W2096572397 @default.
- W4248622847 cites W2108667668 @default.
- W4248622847 cites W2130900820 @default.
- W4248622847 cites W2135067095 @default.
- W4248622847 cites W2139085647 @default.
- W4248622847 cites W2148994442 @default.
- W4248622847 cites W2156749394 @default.
- W4248622847 cites W2322996341 @default.
- W4248622847 doi "https://doi.org/10.5858/2010-0048-oar.1" @default.
- W4248622847 hasPublicationYear "2011" @default.
- W4248622847 type Work @default.
- W4248622847 citedByCount "35" @default.
- W4248622847 countsByYear W42486228472012 @default.
- W4248622847 countsByYear W42486228472013 @default.
- W4248622847 countsByYear W42486228472014 @default.
- W4248622847 countsByYear W42486228472015 @default.
- W4248622847 countsByYear W42486228472016 @default.
- W4248622847 countsByYear W42486228472017 @default.
- W4248622847 countsByYear W42486228472019 @default.
- W4248622847 countsByYear W42486228472020 @default.
- W4248622847 countsByYear W42486228472021 @default.
- W4248622847 countsByYear W42486228472022 @default.
- W4248622847 countsByYear W42486228472023 @default.
- W4248622847 crossrefType "journal-article" @default.
- W4248622847 hasAuthorship W4248622847A5024067229 @default.
- W4248622847 hasAuthorship W4248622847A5029367587 @default.
- W4248622847 hasAuthorship W4248622847A5030798278 @default.
- W4248622847 hasAuthorship W4248622847A5056955251 @default.
- W4248622847 hasBestOaLocation W42486228471 @default.
- W4248622847 hasConcept C104317684 @default.
- W4248622847 hasConcept C121608353 @default.
- W4248622847 hasConcept C124942203 @default.
- W4248622847 hasConcept C142724271 @default.
- W4248622847 hasConcept C203014093 @default.
- W4248622847 hasConcept C2777542201 @default.
- W4248622847 hasConcept C2777546739 @default.
- W4248622847 hasConcept C2779013556 @default.
- W4248622847 hasConcept C2779231225 @default.
- W4248622847 hasConcept C2781163425 @default.
- W4248622847 hasConcept C30481170 @default.
- W4248622847 hasConcept C31033888 @default.
- W4248622847 hasConcept C502942594 @default.
- W4248622847 hasConcept C54355233 @default.
- W4248622847 hasConcept C71924100 @default.
- W4248622847 hasConcept C86803240 @default.
- W4248622847 hasConceptScore W4248622847C104317684 @default.
- W4248622847 hasConceptScore W4248622847C121608353 @default.
- W4248622847 hasConceptScore W4248622847C124942203 @default.
- W4248622847 hasConceptScore W4248622847C142724271 @default.
- W4248622847 hasConceptScore W4248622847C203014093 @default.
- W4248622847 hasConceptScore W4248622847C2777542201 @default.
- W4248622847 hasConceptScore W4248622847C2777546739 @default.
- W4248622847 hasConceptScore W4248622847C2779013556 @default.
- W4248622847 hasConceptScore W4248622847C2779231225 @default.