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• W4248657487 abstract "The human breast cancer resistance protein is an ATP-binding cassette (ABC) multidrug transporter that affects the bioavailability of chemotherapeutic drugs and can confer drug resistance on cancer cells. It is the second member of the ABCG subfamily, other members of which are associated with human steroid disorders such as hypercholesterolemia, sitosterolemia, and atherosclerosis. The molecular bases of protein-steroid interactions in ABC transporters are unknown. Here, we identify a steroid-binding element in the membrane domain of ABCG2 with a similarity to steroid hormone/nuclear receptors. The element facilitates steroid hormone binding and mediates modulation of ABCG2 activity. The identification of this element might provide an opportunity for the development of new therapeutic ligands for ABCG2." @default.
• W4248657487 created "2022-05-12" @default.
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• W4248657487 date "2007-10-05" @default.
• W4248657487 modified "2023-09-23" @default.
• W4248657487 title "A Functional Steroid-Binding Element in an ATP-Binding Cassette Multidrug Transporter" @default.
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• W4248657487 doi "https://doi.org/10.1124/mol.107.038299" @default.
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