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- W4248707005 abstract "SummarySummaryNovelty: A novel series of aromatic hydroxyureas and methods of preparation are disclosed. These compounds are claimed for use in lipoxygenase-mediated disease (e.g. arthritis, rheumatoid arthritis, osteoarthritis, allergic rhinitis etc.).Biology: Human monocytes are used to generate IC50 data for 5-LPO, LTB4 and PGE7 (5-LPO, IC50=0.5–48 μM). Results are also given for ex vivo percent inhibition of PGQ writhing (ED50=7.7 to greater than 20 mg/kg).Chemistry: Extensive synthetic details are given for the preparation of this class of compound with forty-four examples. Forty-three derivatives are named within the claims and these include N-1-(6-benzyloxy-1,2,3,4-tetrahydronaphthyl)-N-hydroxyamine and N-1-(5-benzyloxyindanyl)-N-hydroxyamine.Structure:" @default.
- W4248707005 created "2022-05-12" @default.
- W4248707005 date "1992-01-01" @default.
- W4248707005 modified "2023-10-18" @default.
- W4248707005 title "Patent Evaluation: Novel N-hydroxyureas as 5-lipoxygenase Inhibitors" @default.
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- W4248707005 doi "https://doi.org/10.1517/13543776.2.1.17" @default.
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