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- W4248730408 abstract "We investigated the influence of neonatal depletion of serotonin on the developmental reduction of callosal connections in cat visual cortex. Neonatal kittens were injected with 5,7-dihydroxytryptamine. At the age of 3 months, Fast Blue was injected into visual areas of one hemisphere in these and control cats and retrogradely labeled perikarya were mapped in the opposite hemisphere. In both groups callosally projecting neurons were found in a 3–5 mm wide belt centered on the transient zone of areas 17 and 18. However, numbers of labeled neurons were twice higher in the serotonin-depleted cats. We postulate that normally serotonin intensifies the process of axon pruning by augmenting developmental plasticity, therefore its depletion reduced the plasticity and more axons targeting callosal zones were stabilized, even though ectopic projections were still eliminated." @default.
- W4248730408 created "2022-05-12" @default.
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- W4248730408 date "2003-09-05" @default.
- W4248730408 modified "2023-09-27" @default.
- W4248730408 title "Neonatal depletion of serotonin increases the numbers of callosally projecting neurons in cat visual areas 17 and 18" @default.
- W4248730408 doi "https://doi.org/10.1016/s0304-3940(03)00942-x" @default.
- W4248730408 hasPublicationYear "2003" @default.
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