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- W4248751014 abstract "We investigated the mitogenic effect, measured as [ 3 H]thymidine incorporation, of neuropeptide Y (NPY) on smooth muscle cells (SMCs) from human subcutaneous arteries (diameter: 0.4 mm). NPY stimulated DNA synthesis in a concentration-dependent manner, E max 32 ± 5% relative to control. The effect was potently antagonised by the NPY Y 1 receptor antagonist BIBP3226 ((R)-N2-(diphenylacetyl)-N-[(4-hydroxy-phenyl)methyl]-D-arginine-amide), indicating the effect to be mediated via the NPY Y 1 receptor. Noradrenaline (NA) also induced mitogenesis, E max 35 ± 10% relative to control. When added together, NPY and NA potentiated the [ 3 H]thymidine incorporation, E max 109 ± 38% relative to control. Also, this effect seems to be mediated by the NPY Y 1 receptor, since BIBP3226 blocked the effect (44 ± 9% relative to control). The mitogenic effect of NPY and NA, two important transmitters of the sympathetic nervous system, might have clinical consequences on conditions with elevated sympathetic nerve activity.Key words: BIBP3226, mitogenesis, neuropeptide Y, vascular smooth muscle cells." @default.
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- W4248751014 date "2000-03-01" @default.
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- W4248751014 title "Neuropeptide Y stimulates DNA synthesis in human vascular smooth muscle cells through neuropeptide Y Y1 receptors" @default.
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- W4248751014 doi "https://doi.org/10.1139/y99-147" @default.
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