FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248778753> ?p ?o ?g. }

• W4248778753 endingPage "225" @default.
• W4248778753 startingPage "220" @default.
• W4248778753 abstract "Background and Objectives: There is increase in lipid peroxidation with consequent increase in hemolysis when blood is stored in di-(2-ethyl hexyl)phthalate (DEHP) plasticized bags. Studies carried out by us and others have indicated the ability of red cells to synthesize NAD+ from added nicotinic acid. Apart from the role of NAD+ in glycolysis, NADPH is required for reduction of oxidized glutathione to its reduced form by glutathione reductase. Reduced glutathione is an important antioxidant, which protects cell membrane from oxidative damage. Reduced glutathione is also involved in the regeneration of vitamin E, another important membrane antioxidant. In view of these, a study was undertaken to find out the effect of addition of nicotinic acid to the citrate-phosphate-dextrose-adenine (CPDA) solution on lipid peroxidation and integrity of red cells when whole blood is stored in DEHP plasticized bags. Materials and Methods: Blood was collected in Penpol blood storage bags (which is a DEHP plasticized bag) in CPDA solution in the presence and absence of nicotinic acid. Various parameters of lipid peroxidation and membrane stability – level of malondialdehyde (MDA), conjugated dienes, vitamin E, reduced glutathione, plasma Hb and K+, levels of adenosine triphosphate (ATP) and 2,3 diphosphoglycerate (2,3-DPG) were studied in the blood samples after various periods. Results: Plasma Hb and K+ concentrations were significantly lower in the presence of added nicotinic acid both after 28 and 42 days. Concentration of MDA and conjugated dienes was lower and the levels of reduced glutathione and vitamin E higher in the presence of nicotinic acid. ATP levels were not significantly different, but 2,3-DPG levels were higher. pH of the blood was nearer to 7.0 in the presence of nicotinic acid, while leaching out of DEHP into the blood was significantly lower. Conclusion: Inclusion of nicotinic acid in the CPDA solution has a beneficial effect in that (1) it reduces plasma Hb and K+; (2) reduces lipid peroxidation and increases antioxidant protection; (3) maintains pH nearer to 7.0, and (4) decreases the leaching out of DEHP into the blood." @default.
• W4248778753 created "2022-05-12" @default.
• W4248778753 creator A5006018580 @default.
• W4248778753 creator A5012448563 @default.
• W4248778753 creator A5013491004 @default.
• W4248778753 creator A5026967585 @default.
• W4248778753 creator A5060237467 @default.
• W4248778753 creator A5076958484 @default.
• W4248778753 date "1999-06-01" @default.
• W4248778753 modified "2023-10-16" @default.
• W4248778753 title "Decreased Hemolysis and Lipid Peroxidation in Blood during Storage in the Presence of Nicotinic Acid" @default.
• W4248778753 cites W1846762578 @default.
• W4248778753 cites W1996890971 @default.
• W4248778753 cites W2010434758 @default.
• W4248778753 cites W2035522662 @default.
• W4248778753 cites W2041394830 @default.
• W4248778753 cites W2050806539 @default.
• W4248778753 cites W2056695270 @default.
• W4248778753 cites W2060100156 @default.
• W4248778753 cites W2097119232 @default.
• W4248778753 cites W2147872849 @default.
• W4248778753 cites W2168094875 @default.
• W4248778753 cites W2219509325 @default.
• W4248778753 cites W2271456925 @default.
• W4248778753 cites W2414949567 @default.
• W4248778753 cites W4251025995 @default.
• W4248778753 doi "https://doi.org/10.1046/j.1423-0410.1999.7640220.x" @default.
• W4248778753 hasPublicationYear "1999" @default.
• W4248778753 type Work @default.
• W4248778753 citedByCount "18" @default.
• W4248778753 countsByYear W42487787532013 @default.
• W4248778753 countsByYear W42487787532015 @default.
• W4248778753 countsByYear W42487787532016 @default.
• W4248778753 countsByYear W42487787532017 @default.
• W4248778753 countsByYear W42487787532020 @default.
• W4248778753 countsByYear W42487787532021 @default.
• W4248778753 countsByYear W42487787532022 @default.
• W4248778753 crossrefType "journal-article" @default.
• W4248778753 hasAuthorship W4248778753A5006018580 @default.
• W4248778753 hasAuthorship W4248778753A5012448563 @default.
• W4248778753 hasAuthorship W4248778753A5013491004 @default.
• W4248778753 hasAuthorship W4248778753A5026967585 @default.
• W4248778753 hasAuthorship W4248778753A5060237467 @default.
• W4248778753 hasAuthorship W4248778753A5076958484 @default.
• W4248778753 hasConcept C126322002 @default.
• W4248778753 hasConcept C165069038 @default.
• W4248778753 hasConcept C181199279 @default.
• W4248778753 hasConcept C185592680 @default.
• W4248778753 hasConcept C2777551382 @default.
• W4248778753 hasConcept C2778004101 @default.
• W4248778753 hasConcept C2778401633 @default.
• W4248778753 hasConcept C2778760513 @default.
• W4248778753 hasConcept C2779902561 @default.
• W4248778753 hasConcept C2780829032 @default.
• W4248778753 hasConcept C538909803 @default.
• W4248778753 hasConcept C55493867 @default.
• W4248778753 hasConcept C71924100 @default.
• W4248778753 hasConceptScore W4248778753C126322002 @default.
• W4248778753 hasConceptScore W4248778753C165069038 @default.
• W4248778753 hasConceptScore W4248778753C181199279 @default.
• W4248778753 hasConceptScore W4248778753C185592680 @default.
• W4248778753 hasConceptScore W4248778753C2777551382 @default.
• W4248778753 hasConceptScore W4248778753C2778004101 @default.
• W4248778753 hasConceptScore W4248778753C2778401633 @default.
• W4248778753 hasConceptScore W4248778753C2778760513 @default.
• W4248778753 hasConceptScore W4248778753C2779902561 @default.
• W4248778753 hasConceptScore W4248778753C2780829032 @default.
• W4248778753 hasConceptScore W4248778753C538909803 @default.
• W4248778753 hasConceptScore W4248778753C55493867 @default.
• W4248778753 hasConceptScore W4248778753C71924100 @default.
• W4248778753 hasIssue "4" @default.
• W4248778753 hasLocation W42487787531 @default.
• W4248778753 hasOpenAccess W4248778753 @default.
• W4248778753 hasPrimaryLocation W42487787531 @default.
• W4248778753 hasRelatedWork W1997751979 @default.
• W4248778753 hasRelatedWork W2042958718 @default.
• W4248778753 hasRelatedWork W2046419053 @default.
• W4248778753 hasRelatedWork W2052660271 @default.
• W4248778753 hasRelatedWork W2056243237 @default.
• W4248778753 hasRelatedWork W2100566315 @default.
• W4248778753 hasRelatedWork W2152012395 @default.
• W4248778753 hasRelatedWork W2169892970 @default.
• W4248778753 hasRelatedWork W2904352247 @default.
• W4248778753 hasRelatedWork W2783070782 @default.
• W4248778753 hasVolume "76" @default.
• W4248778753 isParatext "false" @default.
• W4248778753 isRetracted "false" @default.
• W4248778753 workType "article" @default.