Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248782014> ?p ?o ?g. }
Showing items 1 to 52 of
52
with 100 items per page.
- W4248782014 endingPage "iii" @default.
- W4248782014 startingPage "iii" @default.
- W4248782014 abstract "The aim of this study was the development of a liposomal formulation containing specific tetraether lipids for the oral administration of the investigational hepatitis B peptide drug Myrcludex B. For this purpose, tetraether lipids were extracted from the extremophilic archaeon Sulfolobus acidocaldarius and purified in order to obtain the desired glycerylcaldityltetraether lipids (GCTE). Myrcludex B was synthesized by solid-phase synthesis and incorporated into liposomes containing 5 mol% of GCTE. These liposomes showed a size, polydispersity index and zeta potential comparable to the standard liposomes. Cryo-EM micrographs of both liposomal formulations displayed low lamellarity, the prerequisite for high drug loading capacity. Long term storage of the GCTE-liposomes was achieved by freeze-drying using 100–500 mM sucrose or trehalose as lyoprotectors. The lyophilized product showed high stability with a recovery rate of 82.7 ± 1.6% of intact Myrcludex B observed after storage for 3 months at −20 °C as compared to a recovery rate of 83.3 ± 1.3% directly after the freeze-drying process. In vivo, the GCTE-liposomal formulation led to substantial enhancement of the liver uptake of iodine-131-labeled Myrcludex B in Wistar rats. 3 h after oral application, approximately 7% of the initial dose (corresponding to a 3.5-fold increase compared to the free peptide) could be detected in the liver. In summary, the GCTE-liposomes enabled efficient oral administration of Myrcludex B and provided long term storage by freeze-drying." @default.
- W4248782014 created "2022-05-12" @default.
- W4248782014 date "2003-05-01" @default.
- W4248782014 modified "2023-10-18" @default.
- W4248782014 title "Full title (Editorial Board)" @default.
- W4248782014 doi "https://doi.org/10.1016/s0167-5877(03)00093-x" @default.
- W4248782014 hasPublicationYear "2003" @default.
- W4248782014 type Work @default.
- W4248782014 citedByCount "0" @default.
- W4248782014 crossrefType "journal-article" @default.
- W4248782014 hasConcept C11432220 @default.
- W4248782014 hasConcept C150903083 @default.
- W4248782014 hasConcept C178790620 @default.
- W4248782014 hasConcept C185154212 @default.
- W4248782014 hasConcept C185592680 @default.
- W4248782014 hasConcept C207001950 @default.
- W4248782014 hasConcept C2778452849 @default.
- W4248782014 hasConcept C43617362 @default.
- W4248782014 hasConcept C55493867 @default.
- W4248782014 hasConcept C84199377 @default.
- W4248782014 hasConcept C86803240 @default.
- W4248782014 hasConceptScore W4248782014C11432220 @default.
- W4248782014 hasConceptScore W4248782014C150903083 @default.
- W4248782014 hasConceptScore W4248782014C178790620 @default.
- W4248782014 hasConceptScore W4248782014C185154212 @default.
- W4248782014 hasConceptScore W4248782014C185592680 @default.
- W4248782014 hasConceptScore W4248782014C207001950 @default.
- W4248782014 hasConceptScore W4248782014C2778452849 @default.
- W4248782014 hasConceptScore W4248782014C43617362 @default.
- W4248782014 hasConceptScore W4248782014C55493867 @default.
- W4248782014 hasConceptScore W4248782014C84199377 @default.
- W4248782014 hasConceptScore W4248782014C86803240 @default.
- W4248782014 hasIssue "1-2" @default.
- W4248782014 hasLocation W42487820141 @default.
- W4248782014 hasOpenAccess W4248782014 @default.
- W4248782014 hasPrimaryLocation W42487820141 @default.
- W4248782014 hasRelatedWork W1897081581 @default.
- W4248782014 hasRelatedWork W1977952516 @default.
- W4248782014 hasRelatedWork W2008180174 @default.
- W4248782014 hasRelatedWork W2053650083 @default.
- W4248782014 hasRelatedWork W2056281534 @default.
- W4248782014 hasRelatedWork W2092636163 @default.
- W4248782014 hasRelatedWork W2098494230 @default.
- W4248782014 hasRelatedWork W2347430548 @default.
- W4248782014 hasRelatedWork W2367228962 @default.
- W4248782014 hasRelatedWork W287193736 @default.
- W4248782014 hasVolume "59" @default.
- W4248782014 isParatext "false" @default.
- W4248782014 isRetracted "false" @default.
- W4248782014 workType "article" @default.