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- W4248794384 abstract "3019 Background: EGFR is involved in several signaling pathways and has been implicated in the oncogenesis and progression of several human solid tumors, thereby enticing itself as a suitable target for anticancer treatment. A polymorphism in the (CA)n dinucleotide repeats in intron 1 of the EGFR gene has recently been correlated with EGFR expression, with the expression levels being in inverse proportion to the lengths of the (CA)n dinucleotide repeats. The aim of this study was to test the hypothesis if longer (CA)n dinucleotide repeats are more common in the Asian population as postulated by Liu et al(Clin. Cancer Res. 2003) as this might have therapeutic implications with regards to treatment with tyrosine kinase inhibitors. Methods: The EGFR intron 1 polymorphism was analysed in three distinct healthy Asian subjects, namely, Chinese (n=96), Malays (n=98) and Indians (n=100). Results:A genotype of 15/16 was the most common amongst the three Asian populations. Short alleles with 15 and 16 repeats were the most common alleles in Asians and their frequencies were significantly higher than those reported for Caucasians. The frequency of allele 20 was 5%, almost 13-fold lower than the findings by Liu et al. Conclusions: Our data show that the frequency of alleles in Asians with different (CA)n dinucleotide repeats differs from the reports by Liu et al. Furthermore, given the association between the (CA)n repeats and EGFR expression, it seems a higher proportion of Asians do overexpress EGFR that might influence their response to tyrosine kinase inhibitors. No significant financial relationships to disclose." @default.
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- W4248794384 date "2004-07-15" @default.
- W4248794384 modified "2023-10-04" @default.
- W4248794384 title "Pharmacogenetics of the epidermal growth factor receptor (EGFR) gene in Chinese, Malay and Indian populations" @default.
- W4248794384 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.3019" @default.
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