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- W4248806980 abstract "Abstract Background: Phosphatase of regenerating liver-3 ( PRL-3 ) was involved in a variety of malignancies. In this study, we investigated the expression pattern of PRL-3 and its prognostic significance in prostate cancer (PCa). Methods: The expression profiles of PRL-3 in 126 pairs PCa tissues and adjacent normal specimens were analyzed by quantitative rreal-time polymerase chain reaction (qRT-PCR). Chi-square test was used to estimate the association of PRL-3 level with clinicopathological factors. Survival analysis was performed by Kaplan-Meier method with log rank test. Prognosis analysis was carried out using Cox proportional hazard models. Results: PRL-3 expression was significantly up-regulated in PCa tissues compared to that in normal controls ( P <0.001). Moreover, the expression of PRL-3 was positively associated with lymph node metastasis ( P =0.038), Gleason score ( P =0.003) and lymphovascular invasion ( P =0.013). High PRL-3 expression predicted poor overall survival (OS) (log rank test, P =0.019) and dismal BCR-free survival (log rank test, P =0.021) for PCa patients. PRL-3 was an independent prognostic factor for OS (HR=2.619, 95%CI=1.129-6.076, P =0.025) and BCR-free survival (HR=2.120, 95%CI=1.095-4.105, P =0.026) in PCa. Conclusions: PRL-3 expression is elevated in PCa, and exhibits positive association with malignant tumor progression. PRL-3 may serve as a prognostic biomarker for patients with PCa." @default.
- W4248806980 created "2022-05-12" @default.
- W4248806980 creator A5056485541 @default.
- W4248806980 creator A5077809943 @default.
- W4248806980 date "2020-07-28" @default.
- W4248806980 modified "2023-09-24" @default.
- W4248806980 title "Relationship of Common Variants in PRL-3 Gene With Susceptibility and Prognosis of Prostate Cancer" @default.
- W4248806980 doi "https://doi.org/10.21203/rs.3.rs-48541/v1" @default.
- W4248806980 hasPublicationYear "2020" @default.
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