Matches in SemOpenAlex for { <https://semopenalex.org/work/W4248869179> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W4248869179 endingPage "585" @default.
- W4248869179 startingPage "582" @default.
- W4248869179 abstract "The effect of pure synthetic PAF (1–0-alkyl-2-acetyl-sn-glycero-3- phosphorylcholine) was studied in human platelets. PAF (0.2--2.0 micrograms/ml) produced a dose-dependent aggregation in human platelet- rich plasma (PRP) or platelet suspension obtained by gel-filtration (GFP). In addition, PAF (0.8 microgram/ml) induced secretion of 14C- serotonin (45% +/- 10%; mean +/- SD, n = 9) and platelet factor 4 (PF4) (12.89 +/- 3.81 micrograms/10(9) platelets; n = 9) in PRP. Similar results were obtained in GFP. Aggregation and release of 14C-serotonin and PF4 were inhibited by the metabolic inhibitors 2-deoxyglucose (16.7 mM) and antimycin-A (8.3 micrograms/ml), by the membrane-active drugs mepacrine (10 microM) and chlorpromazine (0.025 mM), by PGI2 (5.34 nM), which elevates intracellular c-AMP, by indomethacin (10 microM) or aspirin (100 microM). The ADP scavengers, creatine phosphate and creatine phosphokinase (CP/CPK), inhibited the second wave of aggregation but not secretion. These data suggest that the major effect of PAF on human platelets is mediated through the cyclo-oxygenase pathway and not through a third pathway." @default.
- W4248869179 created "2022-05-12" @default.
- W4248869179 creator A5027839121 @default.
- W4248869179 creator A5030353979 @default.
- W4248869179 creator A5056592519 @default.
- W4248869179 creator A5087376010 @default.
- W4248869179 date "1982-03-01" @default.
- W4248869179 modified "2023-10-17" @default.
- W4248869179 title "Effect of platelet-activating factor (PAF) on human platelets" @default.
- W4248869179 doi "https://doi.org/10.1182/blood.v59.3.582.bloodjournal593582" @default.
- W4248869179 hasPublicationYear "1982" @default.
- W4248869179 type Work @default.
- W4248869179 citedByCount "0" @default.
- W4248869179 crossrefType "journal-article" @default.
- W4248869179 hasAuthorship W4248869179A5027839121 @default.
- W4248869179 hasAuthorship W4248869179A5030353979 @default.
- W4248869179 hasAuthorship W4248869179A5056592519 @default.
- W4248869179 hasAuthorship W4248869179A5087376010 @default.
- W4248869179 hasBestOaLocation W42488691791 @default.
- W4248869179 hasConcept C126322002 @default.
- W4248869179 hasConcept C134018914 @default.
- W4248869179 hasConcept C159973064 @default.
- W4248869179 hasConcept C185592680 @default.
- W4248869179 hasConcept C2776833585 @default.
- W4248869179 hasConcept C2779020240 @default.
- W4248869179 hasConcept C2779965811 @default.
- W4248869179 hasConcept C28859421 @default.
- W4248869179 hasConcept C36880943 @default.
- W4248869179 hasConcept C55493867 @default.
- W4248869179 hasConcept C71924100 @default.
- W4248869179 hasConcept C86803240 @default.
- W4248869179 hasConcept C89560881 @default.
- W4248869179 hasConcept C98274493 @default.
- W4248869179 hasConceptScore W4248869179C126322002 @default.
- W4248869179 hasConceptScore W4248869179C134018914 @default.
- W4248869179 hasConceptScore W4248869179C159973064 @default.
- W4248869179 hasConceptScore W4248869179C185592680 @default.
- W4248869179 hasConceptScore W4248869179C2776833585 @default.
- W4248869179 hasConceptScore W4248869179C2779020240 @default.
- W4248869179 hasConceptScore W4248869179C2779965811 @default.
- W4248869179 hasConceptScore W4248869179C28859421 @default.
- W4248869179 hasConceptScore W4248869179C36880943 @default.
- W4248869179 hasConceptScore W4248869179C55493867 @default.
- W4248869179 hasConceptScore W4248869179C71924100 @default.
- W4248869179 hasConceptScore W4248869179C86803240 @default.
- W4248869179 hasConceptScore W4248869179C89560881 @default.
- W4248869179 hasConceptScore W4248869179C98274493 @default.
- W4248869179 hasIssue "3" @default.
- W4248869179 hasLocation W42488691791 @default.
- W4248869179 hasOpenAccess W4248869179 @default.
- W4248869179 hasPrimaryLocation W42488691791 @default.
- W4248869179 hasRelatedWork W103934 @default.
- W4248869179 hasRelatedWork W15025194 @default.
- W4248869179 hasRelatedWork W17074206 @default.
- W4248869179 hasRelatedWork W1962110 @default.
- W4248869179 hasRelatedWork W19653406 @default.
- W4248869179 hasRelatedWork W20449185 @default.
- W4248869179 hasRelatedWork W28106649 @default.
- W4248869179 hasRelatedWork W4480115 @default.
- W4248869179 hasRelatedWork W7596776 @default.
- W4248869179 hasRelatedWork W778577 @default.
- W4248869179 hasVolume "59" @default.
- W4248869179 isParatext "false" @default.
- W4248869179 isRetracted "false" @default.
- W4248869179 workType "article" @default.