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- W4248927150 abstract "Lactylates are an important group of molecules in the food and cosmetic industries. A series of natural halogenated 1-lactylates – chlorosphaerolactyaltes (<b>1</b>-<b>4</b>) – were recently reported from <i>Sphaerospermopsis</i> sp. LEGE 00249. Here, we identify the <i>cly</i> biosynthetic gene cluster, containing all the necessary functionalities to generate and release the natural lactylates. Using a combination of stable isotope-labeled precursor feeding and bioinformatic analysis, we propose that dodecanoic acid and pyruvate are the key building blocks in the biosynthesis of <b>1</b>-<b>4</b>. We additionally report minor analogues of these molecules<b> </b>with varying alkyl chains. The discovery of the <i>cly</i> gene cluster paves the way to accessing industrially-relevant lactylates through pathway engineering." @default.
- W4248927150 created "2022-05-12" @default.
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- W4248927150 date "2020-08-28" @default.
- W4248927150 modified "2023-09-25" @default.
- W4248927150 title "Biosynthesis of Chlorinated Lactylates in Sphaerospermopsis Sp. LEGE 00249" @default.
- W4248927150 doi "https://doi.org/10.26434/chemrxiv.12885476.v1" @default.
- W4248927150 hasPublicationYear "2020" @default.
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