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- W4248927219 abstract "Mycophenolic acid requires routine therapeutic drug monitoring. We evaluated the suitability of a new PETINIA (particle enhanced turbidimetric inhibition immunoassay) assay on the Dimension EXL analyzer for monitoring of mycophenolic acid by comparing values obtained by this assay with a HPLC-UV method.Mycophenolic acid concentrations determined in sera of 60 organ transplant recipients using high performance liquid chromatography combined with ultraviolet detection (HPLC-UV, reference method) and the new immunoassay on the Dimension RxL analyzer.The within and between run precision of the new PETINIA assay was < 10%. The assay was linear for a mycophenolic acid concentration up to 30 μg/mL. When mycophenolic acid concentrations in 60 transplant recipients obtained by the HPLC-UV (x-axis) method were compared with corresponding values obtained by the PETINIA assay (y-axis), the following regression equation was obtained: y = 1.1204 x + 0.0881 (r = 0.983, n = 60).If PETINIA assay is used for therapeutic drug monitoring of mycophenolic acid, caution must be exercised in interpreting serum mycophenolic acid level due to observed positive bias." @default.
- W4248927219 created "2022-05-12" @default.
- W4248927219 date "1999-04-01" @default.
- W4248927219 modified "2023-09-27" @default.
- W4248927219 title "Meeting-at-a-glance" @default.
- W4248927219 doi "https://doi.org/10.1016/s1386-6532(99)90384-0" @default.
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