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- W4248933907 abstract "<p><i>The direct mechanochemical amidation of esters – enabled by ball-milling – is herein described. The operationally simple procedure requires inputs of ester, amine, and sub-stoichiometric KOtBu and is applicable to a preparation of a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of API’s, agrochemicals, and its ability to deliver gram-scale synthesis of active pharmaceuticals and building blocks is demonstrated, all in the absence of a reaction solvent.</i></p>" @default.
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- W4248933907 date "2021-05-13" @default.
- W4248933907 modified "2023-10-11" @default.
- W4248933907 title "Direct Amidation of Esters via Ball Milling" @default.
- W4248933907 doi "https://doi.org/10.26434/chemrxiv.14556153" @default.
- W4248933907 hasPublicationYear "2021" @default.
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