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• W4249015055 endingPage "582" @default.
• W4249015055 startingPage "553" @default.
• W4249015055 abstract "This chapter proposes an approach in which integration of in vitro test systems calls for a modification of the approach to the general safety assessment problem. The initial and most important aspect of a product safety evaluation program is the series of steps that leads to an actual statement of the problem or of the objectives of testing and research programs. The chapter presents the basis for selection of specific tests, such as in vitro models, lethality, and in silico methods. The evaluation of lethality would seem to offer a unique opportunity for the development and use of alternatives. Approaches to alternatives for lethality testing include no living materials at all the structure-activity relationship (SAR) or computer model approaches, those that use no intact higher organisms and those that use lower forms of animal life. For toxicology, SARs have to be a significant and important range of uses." @default.
• W4249015055 created "2022-05-12" @default.
• W4249015055 date "2016-10-31" @default.
• W4249015055 modified "2023-09-29" @default.
• W4249015055 title "THE APPLICATION OF<i>IN VITRO</i>TECHNIQUES IN DRUG SAFETY ASSESSMENT" @default.
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