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- W4249028812 abstract "Abstract Predictability is a key requirement to encompass late‐stage C−H functionalization in synthetic routes. However, prediction (and control) of reaction selectivity is usually challenging, especially for complex substrate structures and elusive transformations such as remote C(sp 3 )−H oxidation, as it requires distinguishing a specific C−H bond from many others with similar reactivity. Developed here is a strategy for predictable, remote C−H oxidation that entails substrate binding to a supramolecular Mn or Fe catalyst followed by elucidation of the conformation of the host‐guest adduct by NMR analysis. These analyses indicate which remote C−H bonds are suitably oriented for the oxidation before carrying out the reaction, enabling prediction of site selectivity. This strategy was applied to late‐stage C(sp 3 )−H oxidation of amino‐steroids at C15 (or C16) positions, with a selectivity tunable by modification of catalyst chirality and metal." @default.
- W4249028812 created "2022-05-12" @default.
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- W4249028812 date "2020-05-20" @default.
- W4249028812 modified "2023-10-14" @default.
- W4249028812 title "Predictable Selectivity in Remote C−H Oxidation of Steroids: Analysis of Substrate Binding Mode" @default.
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- W4249028812 doi "https://doi.org/10.1002/ange.202003078" @default.
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