Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249033362> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W4249033362 abstract "Emerging evidence suggests that Erythropoietin (EPO) protects the myocardium from ischemic injury and promotes beneficial remodelling. However, the role of EPO and its receptor (EPO-R) in mediating cardiac regeneration remains unclear. We hypothese that stem cell homing and proliferation modulated by EPO could contribute to its cardio-protective effects. Epoetin-α (3000 U/kg) was injected along the infarction border after the induction of a rat myocardial infarction (MI) by permanent ligation of the left descending coronary artery. At six weeks after MI, cardiac function was measured by pressure-volume loops in left and right ventricles. Infarction size, angiogenesis and pathologic effects were evaluated. Gene expressions of EPO-R, SDF-1α, CXCR-4, c-kit, eNOS, TNF-α, IL-8, Integrin-β and CdK4 were analyzed by RT-PCR at different time points of the first week (24h, 48h, 96h and 7 days). We found EPO treatment improved left ventricular function both at baseline levels and under Dobutamine stress (tau, cardiac output, stroke work, ejection fraction, dp/dt maximum and minimum, n=11–14, p<0.05) and decreased right ventricular wall stress (maximum and endsystolic pressure, n=5– 8, p<0.05). Infarction size was reduced from 27.8±3.4% to 20.1±2.8% (n=6 – 8, p<0.01). Capillary density was increased from 257.7±24.5 to 338.5±35.9 (vessels per square mm, n=6 – 8, p<0.05). Mortality was decreased from 29.0% to 22.2% (n=53– 69). EPO-R was down regulated in infarcted, peri-infarcted and non infarcted areas at all time points (n=7, p<0.05). Cardiac SDF-1α, CXCR-4 and eNOS gene expressions were increased at 24 hours. C-kit was up regulated significantly at 48 hours compared to 24 hours in the EPO treated hearts. In untreated hearts, c-kit expression remained constant. Proinflammatory cytokines (TNF-β, IL-8 and Integrin-γ) were down regulated. Cell cycle re-entry marker (CdK4) was increased at 24 hours in non infarcted zones. In conclusion, we demonstrate intramyocardium Epoetin-α injection induces an earlier up regulation of stem cell chemoattractants, reduces inflammation, enhances angiogenesis and restores heart function after MI." @default.
- W4249033362 created "2022-05-12" @default.
- W4249033362 creator A5002796314 @default.
- W4249033362 creator A5004218295 @default.
- W4249033362 creator A5005551453 @default.
- W4249033362 creator A5005708049 @default.
- W4249033362 creator A5010607811 @default.
- W4249033362 creator A5020839405 @default.
- W4249033362 creator A5031190525 @default.
- W4249033362 creator A5037426480 @default.
- W4249033362 creator A5045629455 @default.
- W4249033362 creator A5047480214 @default.
- W4249033362 creator A5050821228 @default.
- W4249033362 creator A5055249856 @default.
- W4249033362 creator A5057505206 @default.
- W4249033362 creator A5071798015 @default.
- W4249033362 date "2007-10-16" @default.
- W4249033362 modified "2023-09-23" @default.
- W4249033362 title "Abstract 1063: Intracardiac Injection of Epoetin-α Upregulates Stem Cell Chemoattractant Gene Expression In a Rat Myocardial Infarction Model" @default.
- W4249033362 doi "https://doi.org/10.1161/circ.116.suppl_16.ii_212-d" @default.
- W4249033362 hasPublicationYear "2007" @default.
- W4249033362 type Work @default.
- W4249033362 citedByCount "0" @default.
- W4249033362 crossrefType "journal-article" @default.
- W4249033362 hasAuthorship W4249033362A5002796314 @default.
- W4249033362 hasAuthorship W4249033362A5004218295 @default.
- W4249033362 hasAuthorship W4249033362A5005551453 @default.
- W4249033362 hasAuthorship W4249033362A5005708049 @default.
- W4249033362 hasAuthorship W4249033362A5010607811 @default.
- W4249033362 hasAuthorship W4249033362A5020839405 @default.
- W4249033362 hasAuthorship W4249033362A5031190525 @default.
- W4249033362 hasAuthorship W4249033362A5037426480 @default.
- W4249033362 hasAuthorship W4249033362A5045629455 @default.
- W4249033362 hasAuthorship W4249033362A5047480214 @default.
- W4249033362 hasAuthorship W4249033362A5050821228 @default.
- W4249033362 hasAuthorship W4249033362A5055249856 @default.
- W4249033362 hasAuthorship W4249033362A5057505206 @default.
- W4249033362 hasAuthorship W4249033362A5071798015 @default.
- W4249033362 hasConcept C111566952 @default.
- W4249033362 hasConcept C126322002 @default.
- W4249033362 hasConcept C139940330 @default.
- W4249033362 hasConcept C164705383 @default.
- W4249033362 hasConcept C178853913 @default.
- W4249033362 hasConcept C2777798775 @default.
- W4249033362 hasConcept C2778198053 @default.
- W4249033362 hasConcept C2778534260 @default.
- W4249033362 hasConcept C2779537366 @default.
- W4249033362 hasConcept C2779676291 @default.
- W4249033362 hasConcept C2780394083 @default.
- W4249033362 hasConcept C2781185063 @default.
- W4249033362 hasConcept C500558357 @default.
- W4249033362 hasConcept C71924100 @default.
- W4249033362 hasConcept C78085059 @default.
- W4249033362 hasConceptScore W4249033362C111566952 @default.
- W4249033362 hasConceptScore W4249033362C126322002 @default.
- W4249033362 hasConceptScore W4249033362C139940330 @default.
- W4249033362 hasConceptScore W4249033362C164705383 @default.
- W4249033362 hasConceptScore W4249033362C178853913 @default.
- W4249033362 hasConceptScore W4249033362C2777798775 @default.
- W4249033362 hasConceptScore W4249033362C2778198053 @default.
- W4249033362 hasConceptScore W4249033362C2778534260 @default.
- W4249033362 hasConceptScore W4249033362C2779537366 @default.
- W4249033362 hasConceptScore W4249033362C2779676291 @default.
- W4249033362 hasConceptScore W4249033362C2780394083 @default.
- W4249033362 hasConceptScore W4249033362C2781185063 @default.
- W4249033362 hasConceptScore W4249033362C500558357 @default.
- W4249033362 hasConceptScore W4249033362C71924100 @default.
- W4249033362 hasConceptScore W4249033362C78085059 @default.
- W4249033362 hasIssue "suppl_16" @default.
- W4249033362 hasLocation W42490333621 @default.
- W4249033362 hasOpenAccess W4249033362 @default.
- W4249033362 hasPrimaryLocation W42490333621 @default.
- W4249033362 hasRelatedWork W157292898 @default.
- W4249033362 hasRelatedWork W1993404518 @default.
- W4249033362 hasRelatedWork W2044465216 @default.
- W4249033362 hasRelatedWork W2356763381 @default.
- W4249033362 hasRelatedWork W2359561162 @default.
- W4249033362 hasRelatedWork W2361596193 @default.
- W4249033362 hasRelatedWork W2378400834 @default.
- W4249033362 hasRelatedWork W2392262988 @default.
- W4249033362 hasRelatedWork W3029377117 @default.
- W4249033362 hasRelatedWork W4249033362 @default.
- W4249033362 hasVolume "116" @default.
- W4249033362 isParatext "false" @default.
- W4249033362 isRetracted "false" @default.
- W4249033362 workType "article" @default.