Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249041092> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4249041092 endingPage "662" @default.
- W4249041092 startingPage "657" @default.
- W4249041092 abstract "The deoxythymidine5′-triphosphate (dTTP) analog 3′-fluorothymidine 5′-triphosphate (3′-FdTTP) inhibits DNA synthesis by T4 wild-type, L98 (mutator) and CB121 (antimutator) DNA polymerase. CB121 DNA polymerase is less sensitive by a factor of two than the L98 and T4+ enzymes. Inhibition is not due to incorporation of the analog into DNA. 3′-FdTTP acts competitively to the substrate dTTP. The CB121 polymerase exhibits a higher Ki to Km ratio than the other two enzymes (5.3 vs. 3.3) and thus discriminates better between the substrate dTTP and its analog 3′-FdTTP. 3′-FdTTP inhibits the polymerase-associated 3′-5′ exonuclease activities to the same extent as their polymerase activities. The CB121 3′-5′ exonuclease activity is suppressed only half as much by 3′-FdTTP as by dTTP. The results are discussed in relation to the role of T4 DNA polymerase and its associated 3′-5′ exonuclease in determining the accuracy of DNA replication." @default.
- W4249041092 created "2022-05-12" @default.
- W4249041092 creator A5045530097 @default.
- W4249041092 creator A5062255667 @default.
- W4249041092 date "1980-01-01" @default.
- W4249041092 modified "2023-09-26" @default.
- W4249041092 title "Inhibitor studies of phage T4 wild-type and mutant DNA polymerase. IV. The substrate analog 3′-fluorothymidine 5′-triphosphate" @default.
- W4249041092 cites W1496473675 @default.
- W4249041092 cites W1501149994 @default.
- W4249041092 cites W1512345015 @default.
- W4249041092 cites W1518934584 @default.
- W4249041092 cites W1533992712 @default.
- W4249041092 cites W1565208875 @default.
- W4249041092 cites W1588725588 @default.
- W4249041092 cites W1589344673 @default.
- W4249041092 cites W1594104389 @default.
- W4249041092 cites W1609582576 @default.
- W4249041092 cites W1974851475 @default.
- W4249041092 cites W2014427187 @default.
- W4249041092 cites W2052679757 @default.
- W4249041092 cites W2054411709 @default.
- W4249041092 cites W2096595259 @default.
- W4249041092 cites W4237216547 @default.
- W4249041092 cites W4248459005 @default.
- W4249041092 doi "https://doi.org/10.1002/jobm.3630201009" @default.
- W4249041092 hasPublicationYear "1980" @default.
- W4249041092 type Work @default.
- W4249041092 citedByCount "5" @default.
- W4249041092 crossrefType "journal-article" @default.
- W4249041092 hasAuthorship W4249041092A5045530097 @default.
- W4249041092 hasAuthorship W4249041092A5062255667 @default.
- W4249041092 hasConcept C104317684 @default.
- W4249041092 hasConcept C131140672 @default.
- W4249041092 hasConcept C153911025 @default.
- W4249041092 hasConcept C156719811 @default.
- W4249041092 hasConcept C164965036 @default.
- W4249041092 hasConcept C185592680 @default.
- W4249041092 hasConcept C2756471 @default.
- W4249041092 hasConcept C2777501222 @default.
- W4249041092 hasConcept C31254050 @default.
- W4249041092 hasConcept C49105822 @default.
- W4249041092 hasConcept C54415193 @default.
- W4249041092 hasConcept C552990157 @default.
- W4249041092 hasConcept C55493867 @default.
- W4249041092 hasConcept C64241487 @default.
- W4249041092 hasConcept C73573662 @default.
- W4249041092 hasConcept C76535049 @default.
- W4249041092 hasConcept C82381507 @default.
- W4249041092 hasConcept C86803240 @default.
- W4249041092 hasConcept C88354546 @default.
- W4249041092 hasConceptScore W4249041092C104317684 @default.
- W4249041092 hasConceptScore W4249041092C131140672 @default.
- W4249041092 hasConceptScore W4249041092C153911025 @default.
- W4249041092 hasConceptScore W4249041092C156719811 @default.
- W4249041092 hasConceptScore W4249041092C164965036 @default.
- W4249041092 hasConceptScore W4249041092C185592680 @default.
- W4249041092 hasConceptScore W4249041092C2756471 @default.
- W4249041092 hasConceptScore W4249041092C2777501222 @default.
- W4249041092 hasConceptScore W4249041092C31254050 @default.
- W4249041092 hasConceptScore W4249041092C49105822 @default.
- W4249041092 hasConceptScore W4249041092C54415193 @default.
- W4249041092 hasConceptScore W4249041092C552990157 @default.
- W4249041092 hasConceptScore W4249041092C55493867 @default.
- W4249041092 hasConceptScore W4249041092C64241487 @default.
- W4249041092 hasConceptScore W4249041092C73573662 @default.
- W4249041092 hasConceptScore W4249041092C76535049 @default.
- W4249041092 hasConceptScore W4249041092C82381507 @default.
- W4249041092 hasConceptScore W4249041092C86803240 @default.
- W4249041092 hasConceptScore W4249041092C88354546 @default.
- W4249041092 hasIssue "10" @default.
- W4249041092 hasLocation W42490410921 @default.
- W4249041092 hasOpenAccess W4249041092 @default.
- W4249041092 hasPrimaryLocation W42490410921 @default.
- W4249041092 hasRelatedWork W102270371 @default.
- W4249041092 hasRelatedWork W1968784815 @default.
- W4249041092 hasRelatedWork W2017950533 @default.
- W4249041092 hasRelatedWork W2047455537 @default.
- W4249041092 hasRelatedWork W2075074108 @default.
- W4249041092 hasRelatedWork W2084400210 @default.
- W4249041092 hasRelatedWork W2084835764 @default.
- W4249041092 hasRelatedWork W2911713005 @default.
- W4249041092 hasRelatedWork W3174036188 @default.
- W4249041092 hasRelatedWork W337152687 @default.
- W4249041092 hasVolume "20" @default.
- W4249041092 isParatext "false" @default.
- W4249041092 isRetracted "false" @default.
- W4249041092 workType "article" @default.