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- W4249058210 abstract "Gaucher disease, the most common lysosomal storage disease, is caused by a deficiency of glucocerebrosidase resulting in the impairment of glucosylceramide degradation. The hallmark of the disease is the presence of the Gaucher cell, a macrophage containing much of the stored glucosylceramide found in tissues, which is believed to cause many of the clinical manifestations of the disease. We have developed adult mice carrying the Gaucher disease L444P point mutation in the glucocerebrosidase (Gba) gene and exhibiting a partial enzyme deficiency. The mutant mice demonstrate multisystem inflammation, including evidence of B cell hyperproliferation, an aspect of the disease found in some patients. However, the mutant mice do not accumulate large amounts of glucosylceramide or exhibit classic Gaucher cells in tissues." @default.
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- W4249058210 date "2002-05-01" @default.
- W4249058210 modified "2023-09-27" @default.
- W4249058210 title "Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage" @default.
- W4249058210 doi "https://doi.org/10.1172/jci200214530" @default.
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