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- W4249069561 abstract "Abstract Utilizing a chiral bicyclic imidazole organocatalyst and adopting a continuous injection process, an alternative route has been developed for the efficient synthesis of chiral phthalidyl ester prodrugs via dynamic kinetic resolution of 3‐hydroxyphthalides through enantioselective acylation (up to 99 % ee ). The computational studies suggest a general base catalytic mechanism differing from the widely accepted nucleophilic catalytic mechanism. The structure analysis of the key transition states shows that the CH‐π interactions and not the previously considered cation/π‐π interactions between the catalyst and substrate is the dominant factor giving rise to the observed stereocontrol." @default.
- W4249069561 created "2022-05-12" @default.
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- W4249069561 date "2020-11-17" @default.
- W4249069561 modified "2023-10-16" @default.
- W4249069561 title "Chiral Bicyclic Imidazole‐Catalyzed Acylative Dynamic Kinetic Resolution for the Synthesis of Chiral Phthalidyl Esters" @default.
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- W4249069561 doi "https://doi.org/10.1002/ange.202012445" @default.
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