Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249072719> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4249072719 abstract "Abstract Background: Cigarette smoking is associated with thicker carotid intima-media thickness (IMT), probably partly through inflammatory pathways. However, to what extent does inflammation mediate the smoking-carotid atherosclerosis association remains unclear. We investigated the mediating effect of inflammation on the association between cigarette smoking and carotid IMT, and quantified the respective contributions of inflammatory markers to this association. Methods: A total of 1,752 participants from Guangzhou Biobank Cohort Study-Cardiovascular Disease Sub-cohort (GBCS-CVD) were included. Using causal mediation analysis under the counterfactual framework, we decomposed total effects of cigarette smoking on IMT into indirect effects (through inflammatory response) and direct effects (not through inflammatory response). Results: After adjusting for traditional risk factors, the indirect effects of per 109/L increment in leukocyte and granulocyte, per mg/L increment in high-sensitivity C-reactive protein (hs-CRP) and per mg/dl increment in fibrinogen on carotid IMT was 0.0028 mm (95% confidence interval (CI), 0.0011, 0.0047), 0.0019 mm (95% CI, 0.0006, 0.0034), 0.0017 mm (95% CI, 0.0006, 0.003) and 0.001 mm (95% CI, 0.0001, 0.0021), respectively. No evidence for a mediating role of lymphocyte was found. The proportion of the smoking-IMT association mediated by leukocyte, granulocyte, hs-CRP and fibrinogen was 12.57% (95% CI, 8.50%, 22.11%), 8.50% (95% CI, 5.76%, 15.09%), 7.64% (95% CI, 5.20%, 13.79%) and 4.48% (95% CI, 3.04%, 8.03%), respectively. Restricting data analysis to men showed similar results. Conclusions: The effects of cigarette smoking on IMT were partly mediated by leukocyte, hs-CRP and fibrinogen. The mediating role of leukocyte was likely mainly driven by higher granulocyte." @default.
- W4249072719 created "2022-05-12" @default.
- W4249072719 creator A5005193969 @default.
- W4249072719 creator A5025039565 @default.
- W4249072719 creator A5026138510 @default.
- W4249072719 creator A5039136529 @default.
- W4249072719 creator A5048946011 @default.
- W4249072719 creator A5060005501 @default.
- W4249072719 creator A5071289091 @default.
- W4249072719 creator A5085142676 @default.
- W4249072719 creator A5087702534 @default.
- W4249072719 date "2019-08-14" @default.
- W4249072719 modified "2023-09-30" @default.
- W4249072719 title "The mediating role of inflammation in the association between cigarette smoking and intima-media thickness: the Guangzhou biobank cohort study" @default.
- W4249072719 doi "https://doi.org/10.21203/rs.2.12720/v1" @default.
- W4249072719 hasPublicationYear "2019" @default.
- W4249072719 type Work @default.
- W4249072719 citedByCount "0" @default.
- W4249072719 crossrefType "posted-content" @default.
- W4249072719 hasAuthorship W4249072719A5005193969 @default.
- W4249072719 hasAuthorship W4249072719A5025039565 @default.
- W4249072719 hasAuthorship W4249072719A5026138510 @default.
- W4249072719 hasAuthorship W4249072719A5039136529 @default.
- W4249072719 hasAuthorship W4249072719A5048946011 @default.
- W4249072719 hasAuthorship W4249072719A5060005501 @default.
- W4249072719 hasAuthorship W4249072719A5071289091 @default.
- W4249072719 hasAuthorship W4249072719A5085142676 @default.
- W4249072719 hasAuthorship W4249072719A5087702534 @default.
- W4249072719 hasBestOaLocation W42490727191 @default.
- W4249072719 hasConcept C116567970 @default.
- W4249072719 hasConcept C126322002 @default.
- W4249072719 hasConcept C142724271 @default.
- W4249072719 hasConcept C201903717 @default.
- W4249072719 hasConcept C2776252253 @default.
- W4249072719 hasConcept C2776914184 @default.
- W4249072719 hasConcept C2777843972 @default.
- W4249072719 hasConcept C2779036427 @default.
- W4249072719 hasConcept C2779339615 @default.
- W4249072719 hasConcept C2781195455 @default.
- W4249072719 hasConcept C2987047532 @default.
- W4249072719 hasConcept C44249647 @default.
- W4249072719 hasConcept C60644358 @default.
- W4249072719 hasConcept C71924100 @default.
- W4249072719 hasConcept C72563966 @default.
- W4249072719 hasConcept C86803240 @default.
- W4249072719 hasConcept C90924648 @default.
- W4249072719 hasConceptScore W4249072719C116567970 @default.
- W4249072719 hasConceptScore W4249072719C126322002 @default.
- W4249072719 hasConceptScore W4249072719C142724271 @default.
- W4249072719 hasConceptScore W4249072719C201903717 @default.
- W4249072719 hasConceptScore W4249072719C2776252253 @default.
- W4249072719 hasConceptScore W4249072719C2776914184 @default.
- W4249072719 hasConceptScore W4249072719C2777843972 @default.
- W4249072719 hasConceptScore W4249072719C2779036427 @default.
- W4249072719 hasConceptScore W4249072719C2779339615 @default.
- W4249072719 hasConceptScore W4249072719C2781195455 @default.
- W4249072719 hasConceptScore W4249072719C2987047532 @default.
- W4249072719 hasConceptScore W4249072719C44249647 @default.
- W4249072719 hasConceptScore W4249072719C60644358 @default.
- W4249072719 hasConceptScore W4249072719C71924100 @default.
- W4249072719 hasConceptScore W4249072719C72563966 @default.
- W4249072719 hasConceptScore W4249072719C86803240 @default.
- W4249072719 hasConceptScore W4249072719C90924648 @default.
- W4249072719 hasLocation W42490727191 @default.
- W4249072719 hasLocation W42490727192 @default.
- W4249072719 hasOpenAccess W4249072719 @default.
- W4249072719 hasPrimaryLocation W42490727191 @default.
- W4249072719 hasRelatedWork W1964044955 @default.
- W4249072719 hasRelatedWork W1967840298 @default.
- W4249072719 hasRelatedWork W1980827916 @default.
- W4249072719 hasRelatedWork W2110359579 @default.
- W4249072719 hasRelatedWork W2183994184 @default.
- W4249072719 hasRelatedWork W2379161342 @default.
- W4249072719 hasRelatedWork W2563290621 @default.
- W4249072719 hasRelatedWork W3183986273 @default.
- W4249072719 hasRelatedWork W4249072719 @default.
- W4249072719 hasRelatedWork W58764260 @default.
- W4249072719 isParatext "false" @default.
- W4249072719 isRetracted "false" @default.
- W4249072719 workType "article" @default.