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- W4249088486 abstract "Low frequency noise (LFN) (≤ 500 Hz, including infrasound) is a genotoxic agent of disease which impinges on the respiratory tract. In LFN-exposed rat models, the respiratory tract cellular populations become dramatically altered: a) tubulin-based structures, such as tracheal cilia, lose tension becoming wilted, or appear sheared, as if clipped, despite an intact internal axoneme structure, and b) actin-based structures, such as brush cell microvilli, appear fused. In the cochlea of LFN-exposed rats, actin-based stereocilia are also fused, and in human pericardia of LFN-exposed individuals, no cilia have been identified, as would be expected. Other actin-based structures of LFN-exposed rats are currently under study and first results will be presented. The biomechanical properties of these biological structures will be reviewed in order to provide preliminary hypotheses that might explain the behavior of these cellular components in the presence of acoustical energy in the form of LFN." @default.
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- W4249088486 date "2005-01-01" @default.
- W4249088486 modified "2023-09-26" @default.
- W4249088486 title "Actin- & Tubulin-Based structures under low frequency noise stress" @default.
- W4249088486 doi "https://doi.org/10.1016/b978-008044648-6/50140-3" @default.
- W4249088486 hasPublicationYear "2005" @default.
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