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- W4249095264 abstract "Abstract Mannose-oligosaccharide (MOS) pre-biotics are widely deployed in animal agriculture as immunomodulators as well as to enhance growth and gut health. Their mode of action is thought to be mediated through their impact on host microbial communities and associated metabolism. Bio-MOS is a commercially available pre-biotic currently used in the agri-feed industry. To assay Bio-MOS for potential use as a pre-biotic growth promotor in salmonid aquaculture, we modified an established Atlantic salmon in vitro gut model, SalmoSim, to evaluate its impact on host microbial communities. In biological triplicate, microbial communities were stabilised in SalmoSim followed by twenty-day exposure to the pre-biotic and then an eight day ‘wash out’ period. Exposure the MOS resulted in a significant increase in formate (p=0.001), propionate (p=0.037) and isovalerate (p=0.024) levels, correlated with increased abundances of several principally anaerobic microbial genera ( Fusobacteria, Agarivorans, Pseudoalteromonas, Myroides ). 16S rDNA sequencing confirmed a significant shift in microbial community composition in response to supplementation. In conjunction with previous in vivo studies linking enhanced VFA production alongside MOS supplementation to host growth and performance, our data suggest that Bio-MOS may be of value in salmonid production. Furthermore, our data highlight the potential role of in vitro gut models to augment in vivo trials of microbiome modulators." @default.
- W4249095264 created "2022-05-12" @default.
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- W4249095264 date "2020-10-07" @default.
- W4249095264 modified "2023-09-26" @default.
- W4249095264 title "Deploying andin vitrogut model to assay the impact of a mannan-oligosaccharide prebiotic, Bio-MOS® on the Atlantic salmon (Salmo salar) gut microbiome" @default.
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- W4249095264 doi "https://doi.org/10.1101/2020.10.07.328427" @default.
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