Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249098504> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W4249098504 endingPage "493" @default.
- W4249098504 startingPage "488" @default.
- W4249098504 abstract "Expression of both the c-fos and c-sis protooncogenes during myeloid differentiation has been detected in cells of the monocytic lineage. Since an increase in c-fos transcripts was not detected during dimethylsulfoxide induced HL-60 granulocytic differentiation, it was suggested that within the myeloid series c-fos gene expression might be lineage specific. In the present study, we have determined whether expression of the c-fos and c-sis genes is indeed specific for the monocytic pathway or rather common to both the granulocyte and monocyte pathways. C-fos and c-sis gene expression was analyzed in freshly isolated human granulocytes and monocytes, in human HL-60 promyelocytic leukemia cells induced to differentiate along the granulocytic or monocytic pathway, in myeloblasts from five patients with the M1 or M2 subtype of acute myeloblastic leukemia (AML) and in blasts from six patients with M4 myelomonocytic leukemia. The level of c-fos mRNA was fifteen times higher in granulocytes as compared with monocytes. An increase in c-fos expression was also found in HL-60 cells differentiated along the granulocytic pathway after exposure to hypoxanthine, hexamethylene bisacetamide, and the combination of retinoic acid and dibutyryl adenosine 3′5′ cyclic monophosphate. Three of 5 M1 and M2 leukemic myeloblast preparations depleted of lymphoid and monocytic cells and all six M4 leukemic cells expressed c-fos transcripts. In contrast, c-sis gene transcripts were detectable in monocytes and during drug induced monocytic differentiation of the HL- 60 cells but not in granulocytes during granulocytic differentiation of the HL-60 cells or in AML samples. Thus, in the myeloid series, c-sis gene expression is lineage specific while expression of the c-fos gene is found in both lineages and may be related to metabolic pathways common to both granulocytes and monocytes." @default.
- W4249098504 created "2022-05-12" @default.
- W4249098504 creator A5012520002 @default.
- W4249098504 creator A5031618940 @default.
- W4249098504 creator A5056698898 @default.
- W4249098504 creator A5066583447 @default.
- W4249098504 date "1988-02-01" @default.
- W4249098504 modified "2023-09-29" @default.
- W4249098504 title "c-sis but not c-fos gene expression is lineage specific in human myeloid cells" @default.
- W4249098504 doi "https://doi.org/10.1182/blood.v71.2.488.bloodjournal712488" @default.
- W4249098504 hasPublicationYear "1988" @default.
- W4249098504 type Work @default.
- W4249098504 citedByCount "0" @default.
- W4249098504 crossrefType "journal-article" @default.
- W4249098504 hasAuthorship W4249098504A5012520002 @default.
- W4249098504 hasAuthorship W4249098504A5031618940 @default.
- W4249098504 hasAuthorship W4249098504A5056698898 @default.
- W4249098504 hasAuthorship W4249098504A5066583447 @default.
- W4249098504 hasBestOaLocation W42490985041 @default.
- W4249098504 hasConcept C104317684 @default.
- W4249098504 hasConcept C124964019 @default.
- W4249098504 hasConcept C148738053 @default.
- W4249098504 hasConcept C1491633281 @default.
- W4249098504 hasConcept C150194340 @default.
- W4249098504 hasConcept C153911025 @default.
- W4249098504 hasConcept C203014093 @default.
- W4249098504 hasConcept C204258353 @default.
- W4249098504 hasConcept C2778461978 @default.
- W4249098504 hasConcept C2778608605 @default.
- W4249098504 hasConcept C2778729363 @default.
- W4249098504 hasConcept C2779282312 @default.
- W4249098504 hasConcept C2779963572 @default.
- W4249098504 hasConcept C2781121885 @default.
- W4249098504 hasConcept C2781184567 @default.
- W4249098504 hasConcept C502942594 @default.
- W4249098504 hasConcept C54355233 @default.
- W4249098504 hasConcept C55493867 @default.
- W4249098504 hasConcept C81885089 @default.
- W4249098504 hasConcept C86803240 @default.
- W4249098504 hasConceptScore W4249098504C104317684 @default.
- W4249098504 hasConceptScore W4249098504C124964019 @default.
- W4249098504 hasConceptScore W4249098504C148738053 @default.
- W4249098504 hasConceptScore W4249098504C1491633281 @default.
- W4249098504 hasConceptScore W4249098504C150194340 @default.
- W4249098504 hasConceptScore W4249098504C153911025 @default.
- W4249098504 hasConceptScore W4249098504C203014093 @default.
- W4249098504 hasConceptScore W4249098504C204258353 @default.
- W4249098504 hasConceptScore W4249098504C2778461978 @default.
- W4249098504 hasConceptScore W4249098504C2778608605 @default.
- W4249098504 hasConceptScore W4249098504C2778729363 @default.
- W4249098504 hasConceptScore W4249098504C2779282312 @default.
- W4249098504 hasConceptScore W4249098504C2779963572 @default.
- W4249098504 hasConceptScore W4249098504C2781121885 @default.
- W4249098504 hasConceptScore W4249098504C2781184567 @default.
- W4249098504 hasConceptScore W4249098504C502942594 @default.
- W4249098504 hasConceptScore W4249098504C54355233 @default.
- W4249098504 hasConceptScore W4249098504C55493867 @default.
- W4249098504 hasConceptScore W4249098504C81885089 @default.
- W4249098504 hasConceptScore W4249098504C86803240 @default.
- W4249098504 hasIssue "2" @default.
- W4249098504 hasLocation W42490985041 @default.
- W4249098504 hasOpenAccess W4249098504 @default.
- W4249098504 hasPrimaryLocation W42490985041 @default.
- W4249098504 hasRelatedWork W30746603 @default.
- W4249098504 hasRelatedWork W33557509 @default.
- W4249098504 hasRelatedWork W35633540 @default.
- W4249098504 hasRelatedWork W36749646 @default.
- W4249098504 hasRelatedWork W41336079 @default.
- W4249098504 hasRelatedWork W52330545 @default.
- W4249098504 hasRelatedWork W58708874 @default.
- W4249098504 hasRelatedWork W6426471 @default.
- W4249098504 hasRelatedWork W6522465 @default.
- W4249098504 hasRelatedWork W15988229 @default.
- W4249098504 hasVolume "71" @default.
- W4249098504 isParatext "false" @default.
- W4249098504 isRetracted "false" @default.
- W4249098504 workType "article" @default.