Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249174890> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W4249174890 endingPage "1078" @default.
- W4249174890 startingPage "1074" @default.
- W4249174890 abstract "Platelets from a patient with a severe lifelong bleeding tendency, which later spontaneously disappeared, lacked intact thrombospondin and glycoprotein (GP) Ia. Before disappearance of the bleeding disorder, results of coagulation studies and platelet aggregation in response to adenosine diphosphate (ADP), arachidonic acid, thrombin, A23187, epinephrine, and ristocetin were normal. In contrast, aggregation only occurred in the presence of collagen or wheat germ agglutinin at unusually high doses of these agonists. The platelets adhered normally to purified bovine and human type I collagen, and they did not spread in the presence of methylated type I collagen. No collagen-induced clot retraction was observed. Two-dimensional gel electrophoretic analyses of platelet proteins and immunologic studies showed that intact thrombospondin and GP Ia were absent. Aggregation in response to collagen could be restored by adding thrombospondin. Disappearance of the bleeding tendency occurred at the onset of menopause; subsequent analyses revealed that thrombospondin and GP Ia were present in platelets and that collagen-induced platelet aggregation was normal. These results suggest that both thrombospondin and GP Ia are essential in collagen-induced platelet aggregation. The spontaneous disappearance of the bleeding tendency may have been related to hormonal influences." @default.
- W4249174890 created "2022-05-12" @default.
- W4249174890 creator A5003709857 @default.
- W4249174890 creator A5024282703 @default.
- W4249174890 creator A5037341064 @default.
- W4249174890 creator A5037964831 @default.
- W4249174890 creator A5041818986 @default.
- W4249174890 creator A5049180479 @default.
- W4249174890 creator A5064343664 @default.
- W4249174890 date "1988-04-01" @default.
- W4249174890 modified "2023-10-14" @default.
- W4249174890 title "Deficiency of intact thrombospondin and membrane glycoprotein Ia in platelets with defective collagen-induced aggregation and spontaneous loss of disorder" @default.
- W4249174890 doi "https://doi.org/10.1182/blood.v71.4.1074.bloodjournal7141074" @default.
- W4249174890 hasPublicationYear "1988" @default.
- W4249174890 type Work @default.
- W4249174890 citedByCount "1" @default.
- W4249174890 crossrefType "journal-article" @default.
- W4249174890 hasAuthorship W4249174890A5003709857 @default.
- W4249174890 hasAuthorship W4249174890A5024282703 @default.
- W4249174890 hasAuthorship W4249174890A5037341064 @default.
- W4249174890 hasAuthorship W4249174890A5037964831 @default.
- W4249174890 hasAuthorship W4249174890A5041818986 @default.
- W4249174890 hasAuthorship W4249174890A5049180479 @default.
- W4249174890 hasAuthorship W4249174890A5064343664 @default.
- W4249174890 hasBestOaLocation W42491748901 @default.
- W4249174890 hasConcept C108625454 @default.
- W4249174890 hasConcept C126322002 @default.
- W4249174890 hasConcept C134018914 @default.
- W4249174890 hasConcept C167814343 @default.
- W4249174890 hasConcept C181199279 @default.
- W4249174890 hasConcept C185592680 @default.
- W4249174890 hasConcept C2776057759 @default.
- W4249174890 hasConcept C2777292125 @default.
- W4249174890 hasConcept C2777399203 @default.
- W4249174890 hasConcept C2780175098 @default.
- W4249174890 hasConcept C2780758401 @default.
- W4249174890 hasConcept C2910422434 @default.
- W4249174890 hasConcept C2993802102 @default.
- W4249174890 hasConcept C55493867 @default.
- W4249174890 hasConcept C55728118 @default.
- W4249174890 hasConcept C71924100 @default.
- W4249174890 hasConcept C86803240 @default.
- W4249174890 hasConcept C89560881 @default.
- W4249174890 hasConceptScore W4249174890C108625454 @default.
- W4249174890 hasConceptScore W4249174890C126322002 @default.
- W4249174890 hasConceptScore W4249174890C134018914 @default.
- W4249174890 hasConceptScore W4249174890C167814343 @default.
- W4249174890 hasConceptScore W4249174890C181199279 @default.
- W4249174890 hasConceptScore W4249174890C185592680 @default.
- W4249174890 hasConceptScore W4249174890C2776057759 @default.
- W4249174890 hasConceptScore W4249174890C2777292125 @default.
- W4249174890 hasConceptScore W4249174890C2777399203 @default.
- W4249174890 hasConceptScore W4249174890C2780175098 @default.
- W4249174890 hasConceptScore W4249174890C2780758401 @default.
- W4249174890 hasConceptScore W4249174890C2910422434 @default.
- W4249174890 hasConceptScore W4249174890C2993802102 @default.
- W4249174890 hasConceptScore W4249174890C55493867 @default.
- W4249174890 hasConceptScore W4249174890C55728118 @default.
- W4249174890 hasConceptScore W4249174890C71924100 @default.
- W4249174890 hasConceptScore W4249174890C86803240 @default.
- W4249174890 hasConceptScore W4249174890C89560881 @default.
- W4249174890 hasIssue "4" @default.
- W4249174890 hasLocation W42491748901 @default.
- W4249174890 hasOpenAccess W4249174890 @default.
- W4249174890 hasPrimaryLocation W42491748901 @default.
- W4249174890 hasRelatedWork W16002089 @default.
- W4249174890 hasRelatedWork W17074206 @default.
- W4249174890 hasRelatedWork W1962110 @default.
- W4249174890 hasRelatedWork W2644079 @default.
- W4249174890 hasRelatedWork W29667720 @default.
- W4249174890 hasRelatedWork W32538106 @default.
- W4249174890 hasRelatedWork W329883 @default.
- W4249174890 hasRelatedWork W34952949 @default.
- W4249174890 hasRelatedWork W4480115 @default.
- W4249174890 hasRelatedWork W4880839 @default.
- W4249174890 hasVolume "71" @default.
- W4249174890 isParatext "false" @default.
- W4249174890 isRetracted "false" @default.
- W4249174890 workType "article" @default.