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- W4249215908 abstract "Long-term survival following lung transplantation has been limited primarily by the development in patients' lungs of a rejection-related obliteration of terminal bronchioles by fibroblasts. It is known to result from frequent and persistent acute lung rejection and its physiological features include a progressive decline in the lung function measurement of forced expiratory volume in 1 s. We report the dramatic effect on this hitherto usually fatal condition of a specific inhibition of purine metabolism at the xanthine oxidase enzyme by the hypoxanthine analogue allopurinol. The effect of this drug in heart-lung transplant patients with deteriorating lung function in reducing the rate of rejection and in stabilizing lung function was apparent over as short a follow-up period as 3 months and in ten patients. Although the follow-up time is short, we believe the effects are so striking as to require reporting although the mechanisms of this phenomenon are not yet well understood." @default.
- W4249215908 created "2022-05-12" @default.
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- W4249215908 date "1992-01-01" @default.
- W4249215908 modified "2023-09-26" @default.
- W4249215908 title "The use of allopurinol in the inhibition of obliterative bronchiolitis of the transplanted lung" @default.
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- W4249215908 doi "https://doi.org/10.1111/tri.1992.5.s1.246" @default.
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