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- W4249218983 abstract "Abstract Alternative splicing (AS) is an important biological process for regulating the expression of various isoforms from a single gene and thus to promote proteome diversity. In this study, RNA-seq data from 15 pairs of esophageal squamous cell carcinoma (ESCC) tissue samples and two cell lines were analyzed. AS events with significant differences between ESCC and matched normal tissues were re-annotated to find protein coding genes or non-coding RNAs. A total of 45,439 AS events was found. Of these, 6,019 (13.25%) significant differentially AS events were identified. Exon skipping (SE) events occupied the largest proportion of abnormal splicing events. Fifteen differential splicing events with the same trends of ΔΨ values in ESCC tissues and cell lines were found. Four pathways and 20 biological processes related to cell junction and migration were significantly enriched. The upregulated splicing factor SF3B4, which regulates 92 gene splicing events, could be a potential prognostic factor of ESCC. Sashimi plotting was applied to show the differentially-spliced genes, including HNRNPC, VCL, ZNF207, KIAA1217, TPM1 and CALD1. These results suggest that cell junction- and migration-related biological processes and KEGG pathways are affected by the AS abnormalities, and aberrant splicing events can be affected by changed expression of splicing factors. In summary, we identified significant differentially AS events which might be related to the development of ESCC." @default.
- W4249218983 created "2022-05-12" @default.
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- W4249218983 date "2020-07-02" @default.
- W4249218983 modified "2023-10-03" @default.
- W4249218983 title "Alterations of RNA Splicing Patterns in Esophagus Squamous Cell Carcinoma" @default.
- W4249218983 doi "https://doi.org/10.21203/rs.3.rs-39232/v1" @default.
- W4249218983 hasPublicationYear "2020" @default.
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