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- W4249232395 endingPage "1834" @default.
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- W4249232395 abstract "Targeted pulmonary vasoactive substances are the cornerstone of treatment in pulmonary arterial hypertension (PAH). Approved drugs act on various receptors and molecules within the pulmonary arteries, mainly causing pulmonary vasodilation and potentially reversing remodeling with consequent improvement of right ventricular function. A key role is attributed to the prostacyclin pathway and especially the prostacyclin receptor (IP). Selexipag is a recently developed, non-prostanoid, oral IP receptor agonist for the treatment of PAH which has been approved in countries/regions including the USA and Europe.We review the discovery and development of drugs targeting IP receptors in PAH and describe preclinical and phase I studies of selexipag. Furthermore, we review important phase II and III selexipag studies and place them into the clinical context of previously approved prostanoids.Oral selexipag offers a promising therapeutic option within the class of available drugs targeting IP receptors. However, its role as first-line therapy based on its efficacy/side-effect profile in current studies is questionable. Most likely, selexipag will be used in combination with other PAH-specific oral drugs. The potential of selexipag to replace or postpone the use of inhaled or parenteral prostanoids needs to be investigated in future trials." @default.
- W4249232395 created "2022-05-12" @default.
- W4249232395 creator A5007818536 @default.
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- W4249232395 creator A5052349036 @default.
- W4249232395 creator A5074285710 @default.
- W4249232395 creator A5083839456 @default.
- W4249232395 date "2016-08-02" @default.
- W4249232395 modified "2023-09-29" @default.
- W4249232395 title "Selexipag for the treatment of pulmonary arterial hypertension" @default.
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- W4249232395 doi "https://doi.org/10.1080/14656566.2016.1215429" @default.
- W4249232395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27467883" @default.
- W4249232395 hasPublicationYear "2016" @default.
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