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• W4249250946 abstract "Journal of Paediatrics and Child HealthVolume 50, Issue 10 p. 836-836 Heads UpFree Access Probiotics in infant colic First published: 06 October 2014 https://doi.org/10.1111/jpc.12719 The attached content has not been published or submitted for publication elsewhere. All authors have contributed significantly, and all authors are in agreement with the content of the manuscript. edited by Craig Mellis (craig.mellis@sydney.edu.au) AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat There has been insufficient evidence to date in favour of probiotics for treating infant colic.1, 2 A recent study3 investigated the use of probiotics to prevent colic. Five hundred eighty-nine term newborns were randomly allocated to receive Lactobacillus reuteri or placebo for 90 days, the primary outcome being the incidence of colic. Parents recorded duration of inconsolable crying per day. Results were overwhelmingly in favour of the probiotic group, leading some to predict that prophylactic use of probiotics may become common practice.4 We believe the study results should be interpreted with caution. No validated criteria were used to define colic, nor was there a relative risk reduction reported for the difference between treatment groups. Additionally, intention-to-treat analysis was not used, and the majority of those lost to follow up were due to unexplained protocol violations . In contrast, a well-defined study5 investigated the use of probiotics in treating established colic and reported no difference between L. reuteri and placebo groups; however, in this study, a different clinical question was addressed. With little known about the long-term safety of probiotics and studies producing contrasting results, we believe probiotics should be used with caution until there is conclusive evidence. References 1Sung V, Collett S, de Gooyer T, Hiscock H, Tang M, Wake M. Probiotics to prevent or treat excessive infant crying: systematic review and meta-analysis. JAMA Pediatr. 2013; 167: 1150– 1157. CrossrefPubMedWeb of Science®Google Scholar 2Anabrees J, Indrio F, Paes B, AlFaleh K. Probiotics for infantile colic: a systematic review. BMC Pediatr. 2013; 13: 186– 194. CrossrefPubMedWeb of Science®Google Scholar 3Indrio F, Di Mauro A, Riezzo G et al. Prophylactic use of a probiotic in the prevention of colic, regurgitation, and functional constipation: a randomized clinical trial. JAMA Pediatr. 2014; 168: 228– 233. CrossrefPubMedWeb of Science®Google Scholar 4Chumpitazi BP, Shulman RJ. Five probiotic drops a day to keep infantile colic away? JAMA Pediatr 2014; 168: 204– 205. CrossrefPubMedWeb of Science®Google Scholar 5Sung V, Hiscock H, Tang MLK et al. Treating infant colic with the probiotic Lactobacillus reuteri: double blind, placebo controlled randomised trial. BMJ 2014; 348: g2107. doi: 10.1136/bmj.g2107. CrossrefPubMedWeb of Science®Google Scholar Submitted by: Kritika Chetty, kritika.chetty@rch.org.au; Conor Hensey, conor.hensey@rch.org.au; Bridget Freyne, bridget.freyne@rch.org.au Volume50, Issue10October 2014Pages 836-836 ReferencesRelatedInformation" @default.
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