Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249251026> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W4249251026 abstract "ABSTRACT Anatomical, molecular, and physiological interactions between astrocytes and neuronal synapses regulate information processing in the brain. The fruit fly Drosophila melanogaster has become a valuable experimental system for genetic manipulation of the nervous system and has enormous potential for elucidating mechanisms that mediate neuron–glia interactions. Here, we show the first electrophysiological recordings from Drosophila astrocytes and characterize their spatial and physiological relationship with particular synapses. Astrocyte intrinsic properties were found to be strongly analogous to those of vertebrate astrocytes, including a passive current‐voltage relationship, low membrane resistance, high capacitance, and dye‐coupling to local astrocytes. Responses to optogenetic stimulation of glutamatergic premotor neurons were correlated directly with anatomy using serial electron microscopy reconstructions of homologous identified neurons and surrounding astrocytic processes. Robust bidirectional communication was present: neuronal activation triggered astrocytic glutamate transport via excitatory amino acid transporter 1 (Eaat1), and blocking Eaat1 extended glutamatergic interneuron‐evoked inhibitory postsynaptic currents in motor neurons. The neuronal synapses were always located within 1 μm of an astrocytic process, but none were ensheathed by those processes. Thus, fly astrocytes can modulate fast synaptic transmission via neurotransmitter transport within these anatomical parameters. J. Comp. Neurol. 524:1979–1998, 2016. © 2016 Wiley Periodicals, Inc." @default.
- W4249251026 created "2022-05-12" @default.
- W4249251026 creator A5011584934 @default.
- W4249251026 creator A5017704900 @default.
- W4249251026 creator A5018040690 @default.
- W4249251026 creator A5020343192 @default.
- W4249251026 creator A5023548733 @default.
- W4249251026 creator A5042603640 @default.
- W4249251026 creator A5072522455 @default.
- W4249251026 creator A5076560819 @default.
- W4249251026 date "2016-05-07" @default.
- W4249251026 modified "2023-10-18" @default.
- W4249251026 title "Astrocytic glutamate transport regulates a Drosophila CNS synapse that lacks astrocyte ensheathment" @default.
- W4249251026 doi "https://doi.org/10.1002/cne.24030" @default.
- W4249251026 hasPublicationYear "2016" @default.
- W4249251026 type Work @default.
- W4249251026 citedByCount "0" @default.
- W4249251026 crossrefType "journal-article" @default.
- W4249251026 hasAuthorship W4249251026A5011584934 @default.
- W4249251026 hasAuthorship W4249251026A5017704900 @default.
- W4249251026 hasAuthorship W4249251026A5018040690 @default.
- W4249251026 hasAuthorship W4249251026A5020343192 @default.
- W4249251026 hasAuthorship W4249251026A5023548733 @default.
- W4249251026 hasAuthorship W4249251026A5042603640 @default.
- W4249251026 hasAuthorship W4249251026A5072522455 @default.
- W4249251026 hasAuthorship W4249251026A5076560819 @default.
- W4249251026 hasBestOaLocation W42492510261 @default.
- W4249251026 hasConcept C112592302 @default.
- W4249251026 hasConcept C127445978 @default.
- W4249251026 hasConcept C169760540 @default.
- W4249251026 hasConcept C170493617 @default.
- W4249251026 hasConcept C17077164 @default.
- W4249251026 hasConcept C197341189 @default.
- W4249251026 hasConcept C200170125 @default.
- W4249251026 hasConcept C2777542381 @default.
- W4249251026 hasConcept C2779296341 @default.
- W4249251026 hasConcept C2780648746 @default.
- W4249251026 hasConcept C529278444 @default.
- W4249251026 hasConcept C55493867 @default.
- W4249251026 hasConcept C61174792 @default.
- W4249251026 hasConcept C86803240 @default.
- W4249251026 hasConceptScore W4249251026C112592302 @default.
- W4249251026 hasConceptScore W4249251026C127445978 @default.
- W4249251026 hasConceptScore W4249251026C169760540 @default.
- W4249251026 hasConceptScore W4249251026C170493617 @default.
- W4249251026 hasConceptScore W4249251026C17077164 @default.
- W4249251026 hasConceptScore W4249251026C197341189 @default.
- W4249251026 hasConceptScore W4249251026C200170125 @default.
- W4249251026 hasConceptScore W4249251026C2777542381 @default.
- W4249251026 hasConceptScore W4249251026C2779296341 @default.
- W4249251026 hasConceptScore W4249251026C2780648746 @default.
- W4249251026 hasConceptScore W4249251026C529278444 @default.
- W4249251026 hasConceptScore W4249251026C55493867 @default.
- W4249251026 hasConceptScore W4249251026C61174792 @default.
- W4249251026 hasConceptScore W4249251026C86803240 @default.
- W4249251026 hasIssue "10" @default.
- W4249251026 hasLocation W42492510261 @default.
- W4249251026 hasLocation W42492510262 @default.
- W4249251026 hasOpenAccess W4249251026 @default.
- W4249251026 hasPrimaryLocation W42492510261 @default.
- W4249251026 hasRelatedWork W1079267665 @default.
- W4249251026 hasRelatedWork W1608388070 @default.
- W4249251026 hasRelatedWork W2012298075 @default.
- W4249251026 hasRelatedWork W2027965057 @default.
- W4249251026 hasRelatedWork W2039958681 @default.
- W4249251026 hasRelatedWork W2094353622 @default.
- W4249251026 hasRelatedWork W2143679348 @default.
- W4249251026 hasRelatedWork W2343911421 @default.
- W4249251026 hasRelatedWork W3086570168 @default.
- W4249251026 hasRelatedWork W3208263584 @default.
- W4249251026 hasVolume "524" @default.
- W4249251026 isParatext "false" @default.
- W4249251026 isRetracted "false" @default.
- W4249251026 workType "article" @default.