Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249262334> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W4249262334 endingPage "4320" @default.
- W4249262334 startingPage "4314" @default.
- W4249262334 abstract "We have previously shown that the cAMP signaling pathway controls major aspects of embryonic red blood cell (RBC) function in avian embryos (Glombitza et al, Am J Physiol 271:R973, 1996; and Dragon et al, Am J Physiol 271:R982, 1996) that are important for adaptation of the RBC gas transport properties to the progressive hypercapnia and hypoxia of later stages of avian embryonic development. Data about the ontogeny of receptor-mediated cAMP signaling are lacking. We have analyzed the response of primitive and definitive chick embryo RBC harvested from day 3 to 18 of development towards forskolin, β-adrenergic, and A2 receptor agonists. The results show a strong response of immature definitive and primitive RBC to adenosine A2 and β-adrenergic receptor agonists, which is drastically reduced in the last stage of development, coincident with the appearance of mature, transcriptionally inactive RBC. Modulation of cGMP-inhibited phosphodiesterase 3 (PDE3) has a controlling influence on cAMP accumulation in definitive RBC. Under physiological conditions, PDE3 is inhibited due to activation of soluble guanylyl cyclase (sGC). Inhibition of sGC with the specific inhibitor ODQ decreases receptor-mediated stimulation of cAMP production; this effect is reversed by the PDE3 inhibitor milrinone. sGC is acitivated by nitric oxide (NO), but we found no evidence for production of NO by erythrocyte NO-synthase. However, embryonic hemoglobin releases NO in an oxygen-linked manner that may activate guanylyl cyclase." @default.
- W4249262334 created "2022-05-12" @default.
- W4249262334 creator A5029936282 @default.
- W4249262334 creator A5041361285 @default.
- W4249262334 creator A5049335077 @default.
- W4249262334 creator A5090550454 @default.
- W4249262334 date "1999-12-15" @default.
- W4249262334 modified "2023-09-27" @default.
- W4249262334 title "Ontogeny of Catecholamine and Adenosine Receptor-Mediated cAMP Signaling of Embryonic Red Blood Cells: Role of cGMP-Inhibited Phosphodiesterase 3 and Hemoglobin" @default.
- W4249262334 cites W1580076592 @default.
- W4249262334 cites W2015747269 @default.
- W4249262334 cites W2018656238 @default.
- W4249262334 cites W2059148896 @default.
- W4249262334 cites W2070010571 @default.
- W4249262334 cites W2094089215 @default.
- W4249262334 cites W2095115132 @default.
- W4249262334 cites W2096284229 @default.
- W4249262334 cites W2285274971 @default.
- W4249262334 cites W2299360809 @default.
- W4249262334 cites W2408745332 @default.
- W4249262334 doi "https://doi.org/10.1182/blood.v94.12.4314.424k16_4314_4320" @default.
- W4249262334 hasPublicationYear "1999" @default.
- W4249262334 type Work @default.
- W4249262334 citedByCount "0" @default.
- W4249262334 crossrefType "journal-article" @default.
- W4249262334 hasAuthorship W4249262334A5029936282 @default.
- W4249262334 hasAuthorship W4249262334A5041361285 @default.
- W4249262334 hasAuthorship W4249262334A5049335077 @default.
- W4249262334 hasAuthorship W4249262334A5090550454 @default.
- W4249262334 hasConcept C126322002 @default.
- W4249262334 hasConcept C134018914 @default.
- W4249262334 hasConcept C170493617 @default.
- W4249262334 hasConcept C181199279 @default.
- W4249262334 hasConcept C24998067 @default.
- W4249262334 hasConcept C2776766087 @default.
- W4249262334 hasConcept C2776991684 @default.
- W4249262334 hasConcept C2779178603 @default.
- W4249262334 hasConcept C55493867 @default.
- W4249262334 hasConcept C58141971 @default.
- W4249262334 hasConcept C62826618 @default.
- W4249262334 hasConcept C71924100 @default.
- W4249262334 hasConcept C86803240 @default.
- W4249262334 hasConcept C95444343 @default.
- W4249262334 hasConceptScore W4249262334C126322002 @default.
- W4249262334 hasConceptScore W4249262334C134018914 @default.
- W4249262334 hasConceptScore W4249262334C170493617 @default.
- W4249262334 hasConceptScore W4249262334C181199279 @default.
- W4249262334 hasConceptScore W4249262334C24998067 @default.
- W4249262334 hasConceptScore W4249262334C2776766087 @default.
- W4249262334 hasConceptScore W4249262334C2776991684 @default.
- W4249262334 hasConceptScore W4249262334C2779178603 @default.
- W4249262334 hasConceptScore W4249262334C55493867 @default.
- W4249262334 hasConceptScore W4249262334C58141971 @default.
- W4249262334 hasConceptScore W4249262334C62826618 @default.
- W4249262334 hasConceptScore W4249262334C71924100 @default.
- W4249262334 hasConceptScore W4249262334C86803240 @default.
- W4249262334 hasConceptScore W4249262334C95444343 @default.
- W4249262334 hasIssue "12" @default.
- W4249262334 hasLocation W42492623341 @default.
- W4249262334 hasOpenAccess W4249262334 @default.
- W4249262334 hasPrimaryLocation W42492623341 @default.
- W4249262334 hasRelatedWork W10496323 @default.
- W4249262334 hasRelatedWork W12278600 @default.
- W4249262334 hasRelatedWork W16920312 @default.
- W4249262334 hasRelatedWork W2516207 @default.
- W4249262334 hasRelatedWork W31306756 @default.
- W4249262334 hasRelatedWork W35438191 @default.
- W4249262334 hasRelatedWork W3676368 @default.
- W4249262334 hasRelatedWork W4533508 @default.
- W4249262334 hasRelatedWork W7889885 @default.
- W4249262334 hasRelatedWork W19245607 @default.
- W4249262334 hasVolume "94" @default.
- W4249262334 isParatext "false" @default.
- W4249262334 isRetracted "false" @default.
- W4249262334 workType "article" @default.