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- W4249264966 abstract "When busy clinicians encounter a new treatment, they ask themselves two questions. First, is it better than (“superior to”) what they are using now? Second, if is not superior, is it as good as what they are using now (“noninferior”) and preferable for some other reason (e.g., fewer side effects or more affordable)? In statistical terms, these clinical questions are “one-sided.” However, traditional statistical concepts call for two-sided tests of statistical significance and require rejection of the null hypothesis. A solution to both this incompatibility (between one-sided clinical reasoning and two-sided statistical testing) and confusion (about the clinical interpretation of statistically nonsignificant results) is now gaining widespread recognition and application. It is encompassed by the concepts of “superiority” and “noninferiority,” and these inextricable concepts are the subjects of this entry." @default.
- W4249264966 created "2022-05-12" @default.
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- W4249264966 date "2014-09-29" @default.
- W4249264966 modified "2023-09-25" @default.
- W4249264966 title "Superiority Trial" @default.
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- W4249264966 doi "https://doi.org/10.1002/9781118445112.stat07125" @default.
- W4249264966 hasPublicationYear "2014" @default.
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