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- W4249269660 abstract "Parathyroid carcinoma is a rare malignancy with an incidence of less than 1 per million population. Adenomatous, hyperplastic, or malignant changes in the parathyroid glands result in the loss of feedback inhibition, increased secretion of parathyroid hormone, and subsequent hypercalcemia. No single gene has been implicated as a cause of parathyroid carcinoma; however, several genes have been linked to the development of this malignancy. Current understanding of the molecular pathogenesis of parathyroid carcinoma is largely the result of the biochemical characterization of hyperparathyroidism–jaw tumor (HPT-JT) and the cloning of the CDC73 tumor suppressor gene. The clinical presentation of patients with parathyroid carcinoma almost invariably results from hypercalcemia due to the parathyroid hormone produced by the tumor. Symptoms include the classical “bones, stones, groans, and psychic moans” associated with hypercalcemia of hyperparathyroidism. The management of this cancer is primarily surgical, although octreotide may help in the control of hypercalcemia, and cytotoxic chemotherapy occasionally produces short-term responses in metastatic disease." @default.
- W4249269660 created "2022-05-12" @default.
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- W4249269660 date "2017-03-11" @default.
- W4249269660 modified "2023-10-17" @default.
- W4249269660 title "Parathyroid Carcinoma" @default.
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- W4249269660 doi "https://doi.org/10.1002/9781119196235.ch49" @default.
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