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• W4249375544 abstract "Objectives: Hypothermia of 32°C–34°C induced after resuscitation from cardiac arrest improves neurologic recovery, but the optimal depth of cooling is unknown. Using a rat model, the authors tested the hypothesis that cooling to 35°C between hours 1 and 24 after resuscitation would improve neurologic outcome as much as cooling to 33°C. Methods: Halothane-anesthetized rats (n= 38) underwent 8 minutes of asphyxial cardiac arrest and resuscitation. Cranial temperature was maintained at 37°C before, during, and after arrest. Between one and 24 hours after resuscitation, cranial temperature was maintained at 33°C, 35°C, or 37°C using computer-controlled cooling fans and heating lamps. Neurologic scores were measured daily, and rats were killed at 14 days for histologic analysis. Neurons per high-powered field were counted in the CA1 region of the anterior hippocampus using neuronal nuclear antigen staining. Results: After 14 days, 12 of 12 rats (100%) cooled to 33°C, 11 of 12 rats (92%) cooled to 35°C, and ten of 14 rats (71%) cooled to 37°C survived, with hazard of death greater in the rats cooled to 37°C than in the combined hypothermia groups. Neurologic scores were worse in the rats cooled to 37°C than in the hypothermia groups on days 1, 2, and 3. Numbers of surviving neurons were similar between the groups cooled to 33°C and 35°C and were higher than in the group cooled to 37°C. Conclusions: These data illustrate that hypothermia of 35°C or 33°C over the first day of recovery improves neurologic scores and neuronal survival after cardiac arrest in rats. The benefit of induced hypothermia of 35°C appears to be similar to the benefit of 33°C." @default.
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• W4249375544 date "2007-04-01" @default.
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• W4249375544 title "Comparison of the Effects of Hypothermia at 33°C or 35°C after Cardiac Arrest in Rats" @default.
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• W4249375544 doi "https://doi.org/10.1111/j.1553-2712.2007.tb02010.x" @default.
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