Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249439051> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4249439051 endingPage "222" @default.
- W4249439051 startingPage "211" @default.
- W4249439051 abstract "The effect of famotidine on gastric lesions induced by the decrease in mucosal defensive resistance was investigated in rats and compared with those of cimetidine, pirenzepine and cetraxate. Famotidine (0.03, 0.1 and 0.3 mg/kg. p.o.) inhibited dose-dependently the development of gastric lesions produced by taurocholatehistamine in doses that suppressed histamine-induced acid secretion in pylorus-ligated rats. The H2-antagonist also prevented gastric mucosal lesions induced by taurocholate-serotonin, iodoacetamide, acidified aspirin and acidified ethanol. Cimetidine, pirenzepine and cetraxate showed the inhibitory effects on almost all types of the gastric lesions, but their inhibitory effects were much less potent than those of famotidine. On the other hand, famotidine inhibited the decreases of gastric mucosal blood flow induced by acidified ethanol and the mucosal contents of glycoprotein induced by water immersion restraint stress. In addition, famotidine increased the transgastric potential difference (PD) and promoted the recovery of decreased transgastric PD induced by acidified ethanol in rats. These results suggest that the preventive effect of famotidine on gastric lesions is attributable not only to suppression of acid secretion but to activation of the gastric mucosal defensive mechanisms." @default.
- W4249439051 created "2022-05-12" @default.
- W4249439051 creator A5044498054 @default.
- W4249439051 creator A5050392839 @default.
- W4249439051 creator A5061810308 @default.
- W4249439051 creator A5081433023 @default.
- W4249439051 date "1991-01-01" @default.
- W4249439051 modified "2023-09-25" @default.
- W4249439051 title "Studies on the Mechanism for the Gastric Mucosal Protection by Famotidine in Rats" @default.
- W4249439051 cites W1480464778 @default.
- W4249439051 cites W1592075299 @default.
- W4249439051 cites W1615012936 @default.
- W4249439051 cites W1752559236 @default.
- W4249439051 cites W1968845866 @default.
- W4249439051 cites W1972552689 @default.
- W4249439051 cites W1979397510 @default.
- W4249439051 cites W1982423051 @default.
- W4249439051 cites W1992603892 @default.
- W4249439051 cites W2006701506 @default.
- W4249439051 cites W2007254610 @default.
- W4249439051 cites W2021360454 @default.
- W4249439051 cites W2021658266 @default.
- W4249439051 cites W2022484322 @default.
- W4249439051 cites W2026116364 @default.
- W4249439051 cites W2032236875 @default.
- W4249439051 cites W2033766631 @default.
- W4249439051 cites W2040569433 @default.
- W4249439051 cites W2046963797 @default.
- W4249439051 cites W2052143930 @default.
- W4249439051 cites W2061440848 @default.
- W4249439051 cites W2062318231 @default.
- W4249439051 cites W2066432891 @default.
- W4249439051 cites W2090000216 @default.
- W4249439051 cites W2104930834 @default.
- W4249439051 cites W2403657425 @default.
- W4249439051 cites W246900166 @default.
- W4249439051 cites W4232863409 @default.
- W4249439051 cites W4296978380 @default.
- W4249439051 doi "https://doi.org/10.1016/s0021-5198(19)39953-6" @default.
- W4249439051 hasPublicationYear "1991" @default.
- W4249439051 type Work @default.
- W4249439051 citedByCount "1" @default.
- W4249439051 countsByYear W42494390512021 @default.
- W4249439051 crossrefType "journal-article" @default.
- W4249439051 hasAuthorship W4249439051A5044498054 @default.
- W4249439051 hasAuthorship W4249439051A5050392839 @default.
- W4249439051 hasAuthorship W4249439051A5061810308 @default.
- W4249439051 hasAuthorship W4249439051A5081433023 @default.
- W4249439051 hasBestOaLocation W42494390511 @default.
- W4249439051 hasConcept C1122143 @default.
- W4249439051 hasConcept C126322002 @default.
- W4249439051 hasConcept C134018914 @default.
- W4249439051 hasConcept C170493617 @default.
- W4249439051 hasConcept C185592680 @default.
- W4249439051 hasConcept C2776885963 @default.
- W4249439051 hasConcept C2777504413 @default.
- W4249439051 hasConcept C2777628954 @default.
- W4249439051 hasConcept C2778616617 @default.
- W4249439051 hasConcept C2779422922 @default.
- W4249439051 hasConcept C2780719153 @default.
- W4249439051 hasConcept C2781263782 @default.
- W4249439051 hasConcept C2909114478 @default.
- W4249439051 hasConcept C71924100 @default.
- W4249439051 hasConcept C98274493 @default.
- W4249439051 hasConceptScore W4249439051C1122143 @default.
- W4249439051 hasConceptScore W4249439051C126322002 @default.
- W4249439051 hasConceptScore W4249439051C134018914 @default.
- W4249439051 hasConceptScore W4249439051C170493617 @default.
- W4249439051 hasConceptScore W4249439051C185592680 @default.
- W4249439051 hasConceptScore W4249439051C2776885963 @default.
- W4249439051 hasConceptScore W4249439051C2777504413 @default.
- W4249439051 hasConceptScore W4249439051C2777628954 @default.
- W4249439051 hasConceptScore W4249439051C2778616617 @default.
- W4249439051 hasConceptScore W4249439051C2779422922 @default.
- W4249439051 hasConceptScore W4249439051C2780719153 @default.
- W4249439051 hasConceptScore W4249439051C2781263782 @default.
- W4249439051 hasConceptScore W4249439051C2909114478 @default.
- W4249439051 hasConceptScore W4249439051C71924100 @default.
- W4249439051 hasConceptScore W4249439051C98274493 @default.
- W4249439051 hasIssue "2" @default.
- W4249439051 hasLocation W42494390511 @default.
- W4249439051 hasOpenAccess W4249439051 @default.
- W4249439051 hasPrimaryLocation W42494390511 @default.
- W4249439051 hasRelatedWork W126684794 @default.
- W4249439051 hasRelatedWork W2020459612 @default.
- W4249439051 hasRelatedWork W2139973343 @default.
- W4249439051 hasRelatedWork W2154818422 @default.
- W4249439051 hasRelatedWork W2272514764 @default.
- W4249439051 hasRelatedWork W2351844585 @default.
- W4249439051 hasRelatedWork W2412730628 @default.
- W4249439051 hasRelatedWork W2438050910 @default.
- W4249439051 hasRelatedWork W4249439051 @default.
- W4249439051 hasRelatedWork W4293578753 @default.
- W4249439051 hasVolume "55" @default.
- W4249439051 isParatext "false" @default.
- W4249439051 isRetracted "false" @default.
- W4249439051 workType "article" @default.