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- W4249440667 abstract "We appreciate the interest in our paper from Drs. Narayanan and Dave.1Benz M.S. Packo K.H. Gonzalez V. et al.A placebo-controlled trial of microplasmin intravitreous injection to facilitate posterior vitreous detachment before vitrectomy.Ophthalmology. 2010; 117: 791-797Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar They bring up 3 separate points needing clarification. With respect to the first point, a separate previous clinical trial found no additional benefit when increasing the dose of microplasmin to 175 μg.2Stalmans P. Delaey C. de Smet M.D. et al.Intravitreal injection of microplasmin for treatment of vitreomacular adhesion: results of a prospective, randomized, sham-controlled phase II trial (the MIVI-IIT trial).Retina. 2010; 30: 1122-1127Crossref PubMed Scopus (116) Google Scholar The optimal dose was determined to be 125 μg, and that is the dose that has undergone further testing in this and in subsequent clinical trials. With respect to the second point, there were a very small number of macular holes enrolled in this trial that were classified by the individual investigator as stage IV, using the Gass classification. We agree that, by definition, a stage IV macular hole should have a posterior vitreous detachment (PVD). We do not know how strictly adherent individual investigators were to the classic Gass descriptions of macular holes. In order to alleviate these concerns, the phase III trial of microplasmin as treatment for symptomatic vitreomacular adhesion, including vitreomacular traction and small macular holes, we employed a central reading center to evaluate all baseline and subsequent optical coherence tomography scans to ensure the presence of a focal vitreomacular adhesion. With respect to the third point, in the Results section of the paper we describe secondary end points in the text. One description of a secondary end point, progression of PVD as graded by the central reading center, is included in the third paragraph of the Results section and erroneously includes a call out to Table 3. Microplasmin before VitrectomyOphthalmologyVol. 118Issue 2PreviewWe read with interest the article by Benz et al.1 We would like to congratulate the authors for describing a novel method of posterior vitreous detachment (PVD) induction. However, we would like to make a few observations. Full-Text PDF" @default.
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- W4249440667 date "2011-02-01" @default.
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- W4249440667 title "Author reply" @default.
- W4249440667 doi "https://doi.org/10.1016/j.ophtha.2010.09.020" @default.
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