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- W4249454671 abstract "The cytoprotective effect of ulinastatin, a Kunitz-type protease inhibitor, was studied in L2 cells treated with antimycin A, which induces depletion of cellular adenosine triphosphate (ATP), so-called «chemical hypoxia». Antimycin A treatment with 2 μM significantly elevated the release of N-acetyl-β-D-glucosaminidase (NAG), a lysosomal enzyme, to 51.99±7.36%. In this condition, ulinastatin tended to inhibit the release of NAG at a concentration of 1000 U/ml (39.74±3.80%) and significantly ameliorated it at a concentration of 3000 U/ml (32.35±4.17%). Furthermore, ulinastatin at 10 U/ml showed a suppression on the fragility of lysosomal membrane isolated from L2 cells. These results indicate that ulinastatin has a prominent protective effect on hypoxic injury in L2 cells, and the lysosomal stabilizing effect is possibly involved as a mechanism of this action." @default.
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- W4249454671 date "1999-04-01" @default.
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- W4249454671 title "Gardner Denver targets centrifugal compressors" @default.
- W4249454671 doi "https://doi.org/10.1016/s1359-6128(99)90895-9" @default.
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