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- W4249468400 abstract "Abstract Background: - Perinatal asphyxia is the third leading cause of neonatal mortality globally, which usually happens within the first week of life. Therefore, evidence-based estimation of neonatal mortality is a cornerstone for tracking progress towards child survival goal and identifying priority areas to improve progress towards eliminating preventable deaths due to perinatal asphyxia. Objective: To assess incidence and predictors of mortality among neonates with perinatal asphyxia admitted to the neonatal intensive care unit of Debre Markos Comprehensive Specialized Hospital, 2021. Methods : An institutional-based retrospective follow-up study was conducted among 402 neonates with perinatal asphyxia (PNA) admitted to the neonatal intensive care unit (NICU) of Debre Markos Comprehensive Specialized Hospital from January 1 st , 2018 to the 30 th of December, 2020. A simple random sampling technique was used to select the estimated sample. Data were entered using Epi data Version 4.6.0.0 and analyzed using Stata Version 14. The Kaplan–Meier and log-rank test were used to estimate and compare the survival time. Both the bi-variable and multivariable Weibull regression models were fitted to identify predictors of mortality. Finally, the Hazard ratio with a 95%CI was computed, and variables with p-values <0.05 were considered as statistically significant predictors of mortality. Results: A total of 125 (31.09%) neonates died during the follow-up period. The overall incidence rate of mortality was found to be 53.49 per 1000 neonate-days of observations (95%CI: 44.89-63.74). Neonatal sepsis (AHR=2.13;95%CI: 1.38-3.27), preterm birth (AHR= 3.42 95%CI; 2.13- 5.48), Hypoxic Ischemic Encephalopathy stage II (AHR=6.65 95%CI: 2.57-17.26), and III (AHR=16.8 95%CI; 6.28- 44.9), Antepartum hemorrhage (AHR=2;95%CI: 1.13-3.92), the induced onset of labor (AHR=3.90;95%CI; 1.83-8.27), and post-partum hemorrhage (AHR=2.12;95%CI: 1.32-3.38) were significant predictors of mortality among neonates with perinatal asphyxia. Conclusion : The study found that the overall incidence rate of mortality among neonates with PNA remains high. Neonatal sepsis, Hypoxic-ischemic encephalopathy stage II and III, preterm birth, antepartum hemorrhage, postpartum hemorrhage and induced onset of labor were independent predictors of mortality. Therefore, early anticipating high-risk pregnancies and newborns with the respective intervention could reduce neonatal due to perinatal asphyxia." @default.
- W4249468400 created "2022-05-12" @default.
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- W4249468400 date "2021-10-29" @default.
- W4249468400 modified "2023-10-16" @default.
- W4249468400 title "Incidence and Predictors of Mortality Among Neonates with Perinatal Asphyxia, Northwest Ethiopia, 2021: An Institution Based Retrospective Cohort Study." @default.
- W4249468400 doi "https://doi.org/10.21203/rs.3.rs-1013476/v1" @default.
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