Matches in SemOpenAlex for { <https://semopenalex.org/work/W4249482882> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W4249482882 abstract "White matter hyperintensities (WMHs) occur in healthy elderly persons as well as patients with Alzheimer's dementia (AD), vascular dementia, and multiple sclerosis. Manual segmentation of WMHs is expensive, time consuming, and vulnerable to inter-rater and test-retest variability. We propose an automated method for segmentation of WMHs from MRI of elderly subjects. Forty adults aged 55 years or older from the PREVENT-AD study had T1-w, T2*, and FLAIR scans. The union of manual WMH labels from two raters were used as “gold standard” for training and validation. All scans were pre-processed using our standard pipeline: image intensity non-uniformity correction, intensity range normalization (0-100), co-registration of T2* and FLAIR to T1-w, and stereotaxic registration of T1-w. The three modalities were then non-linearly warped to an AD template obtained from the ADNI dataset. 17 features served as inputs to the classifier: three MRI intensities (T1-w, T2*, and FLAIR), spatial probability map, intensity distribution probabilities for healthy and WMH tissues (PWM,PWMH) as well as the ratio PWM/PWMH for each modality, and the average intensity of healthy tissue at each voxel for each modality. WMHs were segmented using a linear regression classifier with thresholding yielding low variance, high accuracy and low computation time. Performance was evaluated with 10-fold cross-validation, using Dice Kappa similarity, sensitivity, and specificity to compare automated and manual labels. The mean Dice Kappa, sensitivity, and specificity between automated and manual labels were 0.46, 0.55, and 0.999, respectively. For further validation, total WMH loads were correlated with Fazekas scores of 30 subjects (r=0.80, p=6.44e-7 for periventricular and r=0.55, p=2.8e-3 for deep WMHs) as well as age for the total population (r=0.43, p=1.52e-6). Figures 1.a., 1.b. and 1.c. show the FLAIR images, and automated and manual labels for a subject. Figures 1.d. and 1.e. show Kappa and sensitivity/specificity versus threshold." @default.
- W4249482882 created "2022-05-12" @default.
- W4249482882 creator A5006091170 @default.
- W4249482882 creator A5040791314 @default.
- W4249482882 creator A5042141654 @default.
- W4249482882 creator A5051732001 @default.
- W4249482882 creator A5079184738 @default.
- W4249482882 creator A5091097481 @default.
- W4249482882 date "2015-07-01" @default.
- W4249482882 modified "2023-09-23" @default.
- W4249482882 title "IC-P-139: Accurate automatic segmentation of white matter hyperintensities using a linear regression classifier" @default.
- W4249482882 doi "https://doi.org/10.1016/j.jalz.2015.06.161" @default.
- W4249482882 hasPublicationYear "2015" @default.
- W4249482882 type Work @default.
- W4249482882 citedByCount "0" @default.
- W4249482882 crossrefType "journal-article" @default.
- W4249482882 hasAuthorship W4249482882A5006091170 @default.
- W4249482882 hasAuthorship W4249482882A5040791314 @default.
- W4249482882 hasAuthorship W4249482882A5042141654 @default.
- W4249482882 hasAuthorship W4249482882A5051732001 @default.
- W4249482882 hasAuthorship W4249482882A5079184738 @default.
- W4249482882 hasAuthorship W4249482882A5091097481 @default.
- W4249482882 hasBestOaLocation W42494828821 @default.
- W4249482882 hasConcept C101070640 @default.
- W4249482882 hasConcept C115961682 @default.
- W4249482882 hasConcept C119857082 @default.
- W4249482882 hasConcept C126838900 @default.
- W4249482882 hasConcept C142724271 @default.
- W4249482882 hasConcept C143409427 @default.
- W4249482882 hasConcept C146638467 @default.
- W4249482882 hasConcept C153180895 @default.
- W4249482882 hasConcept C154945302 @default.
- W4249482882 hasConcept C191178318 @default.
- W4249482882 hasConcept C2524010 @default.
- W4249482882 hasConcept C2778724333 @default.
- W4249482882 hasConcept C2779134260 @default.
- W4249482882 hasConcept C2779483572 @default.
- W4249482882 hasConcept C2989005 @default.
- W4249482882 hasConcept C33923547 @default.
- W4249482882 hasConcept C40993552 @default.
- W4249482882 hasConcept C41008148 @default.
- W4249482882 hasConcept C48921125 @default.
- W4249482882 hasConcept C54170458 @default.
- W4249482882 hasConcept C71924100 @default.
- W4249482882 hasConcept C89600930 @default.
- W4249482882 hasConceptScore W4249482882C101070640 @default.
- W4249482882 hasConceptScore W4249482882C115961682 @default.
- W4249482882 hasConceptScore W4249482882C119857082 @default.
- W4249482882 hasConceptScore W4249482882C126838900 @default.
- W4249482882 hasConceptScore W4249482882C142724271 @default.
- W4249482882 hasConceptScore W4249482882C143409427 @default.
- W4249482882 hasConceptScore W4249482882C146638467 @default.
- W4249482882 hasConceptScore W4249482882C153180895 @default.
- W4249482882 hasConceptScore W4249482882C154945302 @default.
- W4249482882 hasConceptScore W4249482882C191178318 @default.
- W4249482882 hasConceptScore W4249482882C2524010 @default.
- W4249482882 hasConceptScore W4249482882C2778724333 @default.
- W4249482882 hasConceptScore W4249482882C2779134260 @default.
- W4249482882 hasConceptScore W4249482882C2779483572 @default.
- W4249482882 hasConceptScore W4249482882C2989005 @default.
- W4249482882 hasConceptScore W4249482882C33923547 @default.
- W4249482882 hasConceptScore W4249482882C40993552 @default.
- W4249482882 hasConceptScore W4249482882C41008148 @default.
- W4249482882 hasConceptScore W4249482882C48921125 @default.
- W4249482882 hasConceptScore W4249482882C54170458 @default.
- W4249482882 hasConceptScore W4249482882C71924100 @default.
- W4249482882 hasConceptScore W4249482882C89600930 @default.
- W4249482882 hasIssue "7S_Part_2" @default.
- W4249482882 hasLocation W42494828821 @default.
- W4249482882 hasOpenAccess W4249482882 @default.
- W4249482882 hasPrimaryLocation W42494828821 @default.
- W4249482882 hasRelatedWork W2033000528 @default.
- W4249482882 hasRelatedWork W2347731544 @default.
- W4249482882 hasRelatedWork W2386894152 @default.
- W4249482882 hasRelatedWork W2411367154 @default.
- W4249482882 hasRelatedWork W2792520941 @default.
- W4249482882 hasRelatedWork W2809233735 @default.
- W4249482882 hasRelatedWork W3108459041 @default.
- W4249482882 hasRelatedWork W3167382736 @default.
- W4249482882 hasRelatedWork W4210718231 @default.
- W4249482882 hasRelatedWork W4362605343 @default.
- W4249482882 hasVolume "11" @default.
- W4249482882 isParatext "false" @default.
- W4249482882 isRetracted "false" @default.
- W4249482882 workType "article" @default.