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• W4249486564 abstract "(Cancer Cell 24, 777–790; December 9, 2013) Following publication of the manuscript, the authors identified an inadvertent error in labeling of the H3K27ac ChIP-Seq tracks at the PAX5 locus in Figure 7E. The revised Figure 7E, shown below, includes the correctly labeled H3K27ac tracks of the PAX5 locus in the indicated cell lines and normal tissue control (tonsil) and illustrates the presence of a PAX5 super-enhancer in each of these cell lines and tonsil. The conclusions remain the same. Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell LymphomaChapuy et al.Cancer CellDecember 09, 2013In BriefDiffuse large B cell lymphoma (DLBCL) is a biologically heterogeneous and clinically aggressive disease. Here, we explore the role of bromodomain and extra-terminal domain (BET) proteins in DLBCL, using integrative chemical genetics and functional epigenomics. We observe highly asymmetric loading of bromodomain 4 (BRD4) at enhancers, with approximately 33% of all BRD4 localizing to enhancers at 1.6% of occupied genes. These super-enhancers prove particularly sensitive to bromodomain inhibition, explaining the selective effect of BET inhibitors on oncogenic and lineage-specific transcriptional circuits. Full-Text PDF Open Archive" @default.
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• W4249486564 date "2014-04-01" @default.
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• W4249486564 title "Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma" @default.
• W4249486564 doi "https://doi.org/10.1016/j.ccr.2014.03.029" @default.
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