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- W4249516581 abstract "3527 Background: Patients with multiple liver metastases are at high risk of recurrence after resection. We assessed whether aggressive multimodality treatment improves 5-year survival (S) from 10% to above 30%. This report provides final results for a prior interim report (Bolton, ASCO 2001, #509). Methods: Patients with M-CRC lesions amenable to resection/cryoablation were eligible. All patients had unfavorable characteristics (>1 bilobar mets +/or >4 mets or satellite lesions). Prior adjuvant chemotherapy for a completely resected primary was allowed. Alternating courses of HAI and SYS included floxuridine (FUDR) via HAI at 0.2 mg/kg, d1–14, on wks 0–2, 5–7, 10–12, and 15–17. SYS chemotherapy consisted of bolus leucovorin 20 mg/m2, plus 5-fluorouracil (5FU) 425 mg/m2, d1–5, on wks 3, 8, 13, and 18. Patients: 49 were completely resected; 44% had >4 hepatic metatases; 78% had bilobar disease; 12% had cryoablation; 36 initiated HAI+SYS. Outcome: Patients received a median of 6 cycles (range 1–8) of HAI/SYS. Median follow-up on treated survivors is 6.2 yrs (range 5.2–9.4). 25 of 36 (78%) receiving HAI+SYS have recurred, with initial site(s) of recurrence as liver only (9), extrahepatic only (10), both (9). Survival (S) and freedom from hepatic recurrence (FHR) rates appear below. Conclusions: This trial of adjuvant chemotherapy in completely resected patients with unfavorable characteristics demonstrates promising 5-yr S [31% (95% CI 19–50%)]. This regimen is an effective option for treatment and should be used as a basis for developing improved treatment regimens in this population. Supported by NIH Grant CA25224. Estimated Kaplan-Meier Rates. No significant financial relationships to disclose." @default.
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- W4249516581 date "2004-07-15" @default.
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- W4249516581 title "Final results of hepatic arterial infusion (HAI) plus systemic (SYS) chemotherapy after multiple metastasectomy in patients with colorectal carcinoma metastatic (M-CRC) to the liver: A North Central Cancer Treatment Group (NCCTG) phase II study" @default.
- W4249516581 doi "https://doi.org/10.1200/jco.2004.22.14_suppl.3527" @default.
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