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• W4249531507 abstract "<h3>Background:</h3> Twenty-four-hour radioactive iodine uptake measurements necessitate extra visits and time delays in diagnostic confirmation of and therapy planning for hyperthyroid patients. We evaluated the early (5 to 6 hours) measurement of iodine 123 uptake (EU) to predict late (24 hours) uptake (LU) and assessed its value in the management of hyperthyroidism. <h3>Methods:</h3> We conducted a prospective study in 51 previously untreated hyperthyroid and 27 euthyroid patients (initial evaluation group). Patients underwent both 6- and 24-hour¹²³I uptake measurements. A subsequent 21 patients with Graves' disease (confirmation group) were evaluated in light of regression data generated in the initial evaluation group. <h3>Results:</h3> An EU value of greater than 20% had a sensitivity of 100%, a specificity of 96%, and a positive predictive value of 98% for the diagnosis of hyperthyroidism and was superior to the most predictive LU value (>30%), which had a sensitivity of 98%, a specificity of 89%, and a positive predictive value of 94%, in distinguishing the hyperthyroid patients from euthyroid patients or those with subacute thyroiditis. Regression analysis revealed that the 24-hour uptake of the hyperthyroid patients could be predicted from the early measurement with the following formula: LU=28.94+0.584 (EU). The measured EU of the confirmation group was used to calculate a predicted LU with use of this formula. Measured LU and predicted LU correlated well (<i>r</i>=.85,<i>P</i><.001). Iodine 131 dose calculations were performed post hoc; LU calculated doses correlated with predicted LU doses (<i>r</i>=.91,<i>P</i><.001). Mean dose differences were small. <h3>Conclusions:</h3> The EU of¹²³I can replace 24-hour uptake measurements. Early uptake measurement is reliable and clinically useful for diagnosis confirmation and treatment planning in thyrotoxic patients. (Arch Intern Med. 1995;155:621-624)" @default.
• W4249531507 created "2022-05-12" @default.
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• W4249531507 date "1995-03-27" @default.
• W4249531507 modified "2023-09-26" @default.
• W4249531507 title "Evaluation of early (5 to 6 hours) iodine 123 uptake for diagnosis and treatment planning in Graves' disease" @default.
• W4249531507 doi "https://doi.org/10.1001/archinte.155.6.621" @default.
• W4249531507 hasPublicationYear "1995" @default.
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