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- W4249583577 abstract "It has been proposed that arginine vasopressin (AVP) contributes to the regulation of renal sodium excretion by direct intrarenal actions, by neural-hormonal interactions, and via secondary effects of fluid volume retention. The present studies were designed to determine the extent to which the natriuretic effects of AVP are secondary to volume expansion. Three groups of dogs were studied: the first was infused with AVP for 2 weeks in amounts that increased plasma levels from 3 to 15 pg/mL, while water intake was maintained constant’by intravenous (iv) water infusion. The second group received the same amount of AVP and was permitted to drink ad libitum. The third group was infused with the same amount of AVP, while total body weight and volume were maintained at a constant level by use of an electronically servocontrolled water infusion system. The results showed a large increase in total body weight (+1.5 kg) and arterial pressure (mean arterial pressure (MAP); +40 mm Hg) in dogs receiving a fixed water intake. This was accompanied by a continuing natriuresis over a 2-week period and severe hyponatremia (115 mEq/L). Dogs allowed ad libitum drinking retained much less fluid (+0.5 kg). MAP was not significantly elevated, and natriuresis did not occur in this group, but hyponatremia was observed (130 mEq/L), and plasma renin activity (PRA) was suppressed. Servo-controlled dogs exhibited no change in MAP, plasma sodium, or PRA, and only a small (–15 mEq) natriuresis occurred on day 1 of AVP infusion. We conclude that AVP exerts substantial natriuretic effects in the presence of volume expansion and that this natreuresis is secondary to reflex-hormonal effects and increased blood pressure." @default.
- W4249583577 created "2022-05-12" @default.
- W4249583577 date "1999-10-01" @default.
- W4249583577 modified "2023-09-28" @default.
- W4249583577 title "Pressing ahead at Dorst" @default.
- W4249583577 doi "https://doi.org/10.1016/s0026-0657(99)81222-3" @default.
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