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- W4249613920 abstract "Abstract Objectives The pediatric urinary tract infection (UTI) often remains under-diagnosed or neglected owing to non-specific clinical presentations, patient failing to describe the actual situation, and of clinical practice in diagnosis—relying upon on in-vitro culture report. The study was aimed to determine the etiologies of UTI in children with enhanced quantitative urine culture technique (EQUC). Results Of 570 urine samples, the significant bacterial growth detected: 16.14% with EQUC, and12.8% with standard urine culture protocol. 20.6% causative isolates to UTI, as detected, with EQUC, missed on standard urine culture (SUC) technique. The age group, in range 1-4 years, was more prone to the infection, where E. coli was the commonest pathogen. EQUC detected the etiologies—MDR, XDR, and ESBL producers; as reported: “no growth” with the SUC technique. 69 E. coli isolates grown with EQUC technique when subjected to susceptibility testing: 46% were ESBL producer, 56.5% were multidrug-resistant (MDR), and 1.4% found extensive drug-resistant (XDR). However, with SUC technique: 40.5% ESBL, 44% MDR but no XDR detected. Hence a simple modification on culture protocol could be a crucial modification for the detection of etiologies contributing UTI, and to reduce inapt antimicrobial burden. Keywords UTI, EQUC, uropathogens, children, ESBL, MDR, XDR" @default.
- W4249613920 created "2022-05-12" @default.
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- W4249613920 date "2019-08-21" @default.
- W4249613920 modified "2023-10-17" @default.
- W4249613920 title "Enhanced quantitative urine culture technique, a slight modification, in detecting under-diagnosed pediatric urinary tract infection" @default.
- W4249613920 doi "https://doi.org/10.21203/rs.2.13342/v1" @default.
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