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- W4249679563 abstract "<h3>SELECTED CASES</h3><h3>CASE 1.</h3> —William Styron, author of several novels, including<i>Lie Down in Darkness, The Confessions of Nat Turner</i>, and<i>Sophie's Choice</i>, became clinically depressed in 1985 at the age of 60 years. In his book,<i>Darkness Visible</i>(the title of which was taken from Milton's description of hell in<i>Paradise Lost</i>), he provides an extraordinary account of the symptoms and course of his illness. I have chosen to include a few of his observations herein because they seem to illustrate important connections between depression, sleep, and a classic symptom of depression—diurnal variation in mood. Styron's depression began when he stopped drinking alcohol. Gradually, he developed anhedonia and feelings of worthlessness and had thoughts of death. Ultimately: The act of writing itself, becoming more and more difficult and exhausting, stalled, then finally ceased. <sup>1(p46)</sup>As is typical in depression, the severity of Styron's symptoms had a striking daily rhythm:" @default.
- W4249679563 created "2022-05-12" @default.
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- W4249679563 date "1992-01-22" @default.
- W4249679563 modified "2023-10-18" @default.
- W4249679563 title "Improvement of depression and triggering of mania by sleep deprivation" @default.
- W4249679563 doi "https://doi.org/10.1001/jama.267.4.548" @default.
- W4249679563 hasPublicationYear "1992" @default.
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